|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, immunisation with RALA/pPSCA loaded MNs elicited a tumour-specific immune response against TRAMP-C1 tumours ex vivo.
|
31299353 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Depletion of AGS3 in the TRAMP-C1 cells (TRAMP-C1-AGS3-/-) decreased cell proliferation and delayed wound healing and tumor growth in both C57BL/6 (~3-fold) and nude mice xenografts, relative to control TRAMP-C1 cells.
|
31215992 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ω3-enriched diet decreased prostate TRAMP-C2 tumor growth in immune-competent eugonadal and castrated mice.
|
30073695 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a preclinical dosage study, B440 significantly inhibited growth of the TRAMP-C2 tumors compared with that of the control groups (PBS and <i>B. longum</i> not expressing WT1) at all dosages (1, 5, and 10 mg/body of B440).
|
30824610 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Prophylactic vaccination with 56 °C-treated TRAMP-C2 tumour cells alone provided protection against TRAMP-C2 tumour growth in vivo, whilst in the therapeutic regimen, control of tumour growth was achieved combining immunization with adjuvant chemotherapy.
|
29752021 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Combination therapy with this hypoxia-prodrug and checkpoint blockade cooperated to cure more than 80% of tumors in the transgenic adenocarcinoma of the mouse prostate-derived (TRAMP-derived) TRAMP-C2 model.
|
30188869 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, a TRAMP-derived Orthotopic Prostate Syngeneic (TOPS) mouse model was developed and found to provide a consistent means of monitoring tumor and metastatic responses to novel treatments.
|
29450905 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Daily intake of this herbal product significantly suppressed the tumor size (<i>P</i> = 0.0368) with lower histopathologic scores (<i>P</i> = 0.0364) in TRAMP mice, which were associated with an increase in both splenocyte cytotoxicity against tumor cells and numbers of CD8 T cells, macrophages, and dendritic cells in the spleens <i>in vivo</i>.
|
29861778 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MG1-Maraba is a potent and versatile oncolytic virus capable of lethally infecting a variety of prostatic tumor cell lines alongside primary PCa biopsies and exerts direct oncolytic effects against large TRAMP-C2 tumors <i>in vivo</i>.
|
29900060 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The gadolinium-doped iron oxide nanoparticles (GdIONP) with greater specific power adsorption rate (SAR) than Fe<sub>3</sub>O<sub>4</sub> was developed and its potential application in tumour therapy and particle tracking were demonstrated in transgenic adenocarcinoma of the mouse prostate C1 (TRAMP-C1) tumours.
|
28540811 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, transfection efficiency of a plasmid co-expressing hSef-b/eGFP into TRAMP C2 tumors was 14.7 ± 2.5% following a single TUS application.
|
29118380 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Five mice bearing TRAMP-C1 tumor were half-irradiated with a dose of 15 Gy.
|
28176411 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conversely, PTX3 overexpression in transgenic mice or treatment with the FGF inhibitor NSC12 result in a significant inhibition of the growth and vascularization of TRAMP-C2 tumor grafts, a murine model of prostate cancer, that were paralleled by a decrease of mast cell infiltrate into the lesion.
|
29137286 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we assessed how hemin, a pharmacologic inducer of heme oxygenase-1 (HO-1), has an impact on prostate cancer development in an <i>in vivo</i> conditioning model.<b>Experimental Design:</b> The stroma of C57BL/6 mice was conditioned by subcutaneous administration of hemin prior to TRAMP-C1 tumor challenge.
|
28512172 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, ABC294640 diminished the growth rate of TRAMP-C2 xenografts in syngeneic hosts and elevated dihydroceramides within tumors as visualized by MALDI imaging mass spectroscopy.
|
26494858 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reports have determined that DR3 may also be distributed in numerous types of tumors.
|
25370568 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Addition of docetaxel to TRAMP-H6, TRAMP-H11, TRAMP-Adv700 vaccines enhanced the infiltration of the tumor by NK cells.
|
26026087 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A similar trend was discernible in the tumors from SFN-treated TRAMP mice compared with those of control mice, but the difference was not significant.
|
25712054 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The TRAMP-C1-specific immune response of spleen lymphocytes from mice bearing HSV-sr39tk- and IL-3-expressing TRAMP-C1 tumors was measured by ELISA.
|
23441198 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ASC-MDA7 only reduced tumor growth in the TRAMP-C2-Ras (TC2Ras) prostate cancer model.
|
21671747 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By breeding TRAMP mice with S100A9 knock-out (S100A9(-/-)) animals and scoring the appearance of palpable tumors we observed a delayed tumor growth in animals devoid of S100A9 expression.
|
22470535 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Prostate tumor cells implanted in mice deficient in atrial natriuretic peptide receptor A (NPRA-KO) failed to grow, and treatment of TRAMP-C1 xenografts with iNPRA reduced tumor burden and MIF expression.
|
21586128 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Regardless of initial tumor size intratumor rVSV-DeltaG-SV5-F administration in mice bearing subcutaneous TRAMP-C2 tumors resulted in a significantly reduced tumor load over that of the nonfusogenic green fluorescent control virus and of heat inactivated recombinant vesicular stomatitis virus in treated animals (p <0.01).
|
20172545 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, in a tumor therapy model, Ad-tWT1 vaccination of TRAMP-C2 tumor-bearing mice significantly suppressed tumor growth.
|
19351755 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effect of thrombin on tumor cell cycle activation and spontaneous growth was examined in synchronized serum-starved tumor cell lines and a model of spontaneous prostate cancer development in TRAMP mice.
|
19351827 |
2009 |