CBR1, carbonyl reductase 1, 873

N. diseases: 100; N. variants: 2
Disease: Cholangiocarcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.030 Biomarker disease BEFREE The NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH/HPGD), a key enzyme that converts the protumorigenic prostaglandin E2 (PGE2) to its biologically inactive metabolite, was identified as a direct target of miR-21 in cholangiocarcinoma cells. 24699315 2014
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.030 Biomarker disease BEFREE 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins. 23687300 2013
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.030 AlteredExpression disease BEFREE Moreover, DHA inhibited the expression of cyclooxygenase-2 (COX-2) and enhanced the expression of 15-hydroxyprostaglandin dehydrogenase, a physiologic COX-2 antagonist, in human cholangiocarcinoma cells. 18199552 2008