TNFSF13, TNF superfamily member 13, 8741

N. diseases: 189; N. variants: 6
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE Taken together, these results define novel APRIL actions via TACI on Tregs and Bregs to promote MM cell survival, providing the rationale for targeting APRIL/TACI system to alleviate the immunosuppressive BM milieu and improve patient outcome in MM. 30135465 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma. 31698455 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 AlteredExpression disease BEFREE Characteristics of BAFF and APRIL factor expression in multiple myeloma and clinical significance. 28928810 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE 01A further decreases APRIL-induced adhesion and migration of MM cells via blockade of canonical and noncanonical NF-κB pathways. 27127303 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE This indicated APRIL consumption by MM in BM. 25753925 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE It was shown that NFkB activation in MM tumors results mainly from extrinsic signaling by APRIL and BAFF ligands that stimulate receptors on normal plasma cells as well as on pre-malignant monoclonal gammopathy of undetermined significance (MGUS) and MM tumors. 20890394 2010
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE BAFF and APRIL stimulate the growth of multiple myeloma (MM) cells. 17550853 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) have been shown to promote multiple myeloma (MM) cell growth. 15827134 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 Biomarker disease BEFREE Altogether, these data suggest that APRIL/BAFF inhibitors may be of clinical value in MM. 15070697 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.090 AlteredExpression disease LHGDN Altogether, these data suggest that APRIL/BAFF inhibitors may be of clinical value in MM. 15070697 2004