|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results point to a plausible role for genetic polymorphisms in <i>IL23R</i> and RIPK2 in the development and severity of AP.
|
31044631 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to explore the mechanisms mediated by RIPK2 in autophagy and the relationship with ROS-NLRP3 of DN, by investigating the levels of RIPK2 and autophagy in glomerular mesangial cells (GMCs) stimulated with high glucose.
|
31485193 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia plays a vital role in diabetic nephropathy (DN); autophagy and its potential upregulator receptor-interacting protein kinase 2 (RIPK2) are associated with ROS, which play a potential role in regulating NLRP3, and may be involved in inflammation in DN.
|
31485193 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, we report for the first time that Rip2 gene silencing ameliorated CS-induced acute lung injury probably via disruption of the NF-κB activity, postulating that Rip2 may be a novel therapeutic target for COPD.
|
30394320 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this article, we have shown that the cytoplasmic receptor Nod-like receptor-2, NOD2, and its adaptor-signaling molecule RIPK2 participate in the development of neuropathic pain after peripheral nerve injury (spared nerve injury model).
|
30169421 |
2019 |
|
Tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our findings firstly exhibit that the G allele of rs39509 in nearGene-3 region of RIPK2 might serve as a hazard for TB in this Western Chinese Han population.
|
31279003 |
2019 |
|
Autoinflammatory disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bridged bicyclic pyrazolocarboxamide <b>11</b> represents a selective and potent inhibitor of RIP2 and will allow for a more detailed investigation of RIP2 inhibition as a therapeutic target for autoinflammatory disorders.
|
31749904 |
2019 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the present study established a negative link between RIP2 and TRAF3 proteins and identifies a new pathway for regulating astrocytoma progression.
|
29693188 |
2018 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytological experiments indicated that RIP2 promoted human glioblastoma cell proliferation by inducing expression of Bcl‑xL, and knockdown of endogenous RIP2 promoted cell apoptosis.
|
29693188 |
2018 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NF‑κB and p38 signaling pathways.
|
29693188 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility.
|
29467894 |
2018 |
|
Meningitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results revealed upregulation of the mRNA and protein levels of NOD2, RIP2, NF-κB, TNF-α and IL-6 within the CNS of mice with S. pneumoniae meningitis.
|
29408491 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Functional analyses of RIPK2 activity in zebrafish embryos indicated that the variant RIPK2104Asp protein is hyperactive in its signaling capacity, with augmented ability to activate the innate immune response and the NF-κB pathway and to promote upregulation of OA-associated genes.
|
29659823 |
2018 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our identified RIPK2 inhibitor may offer possible therapeutic control of inflammation in diseases such as inflammatory bowel disease, asthma, cystic fibrosis, primary sclerosing cholangitis, and pancreatitis.
|
29555876 |
2018 |
|
Sarcoidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, excessive NOD2 signaling has been associated with various diseases, including sarcoidosis and inflammatory arthritis; the pharmacological inhibition of RIPK2 is an affinity strategy that demonstrates an increased expression of pro-inflammatory secretion activity.
|
29463017 |
2018 |
|
Malnutrition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Different from NOD1, the present study showed that NOD1, but not RIP2 deficiency significantly impaired protein levels of MAPK pathways.
|
29692779 |
2018 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytological experiments indicated that RIP2 promoted human glioblastoma cell proliferation by inducing expression of Bcl‑xL, and knockdown of endogenous RIP2 promoted cell apoptosis.
|
29693188 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytological experiments indicated that RIP2 promoted human glioblastoma cell proliferation by inducing expression of Bcl‑xL, and knockdown of endogenous RIP2 promoted cell apoptosis.
|
29693188 |
2018 |
|
Hyperactive behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Functional analyses of RIPK2 activity in zebrafish embryos indicated that the variant RIPK2104Asp protein is hyperactive in its signaling capacity, with augmented ability to activate the innate immune response and the NF-κB pathway and to promote upregulation of OA-associated genes.
|
29659823 |
2018 |
|
Stomach Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility.
|
29467894 |
2018 |
|
Infectious Lung Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
We show that RIP2 deficiency in CD4<sup>+</sup> T cells resulted in chronic and severe interleukin-17A-mediated inflammation during Chlamydia pneumoniae lung infection, increased T helper 17 (Th17) cell formation in lungs of infected mice, accelerated atherosclerosis, and more severe experimental autoimmune encephalomyelitis.
|
30366765 |
2018 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study we show that high expression of RIP2 in breast tumors correlates with a worse prognosis and a higher risk of recurrence.
|
29421659 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Monotherapy with CCKR blockade significantly decreased tumor size and metastases in SCID mice with orthotopic PDAC, and in C57BL/6 mice, it reduced fibrosis and induced the influx of TILs.
|
29043413 |
2018 |
|
malignant neoplasm of breast staging
|
0.010 |
Biomarker
|
disease |
BEFREE |
Indeed, we can demonstrate that RIPK2 activity correlated with advanced tumor, metastasis, and group stage as well as body mass index (BMI) to indicate that RIPK2 might be a useful prognostic marker for IBC and advanced stage breast cancer.
|
29874851 |
2018 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Indeed, we can demonstrate that RIPK2 activity correlated with advanced tumor, metastasis, and group stage as well as body mass index (BMI) to indicate that RIPK2 might be a useful prognostic marker for IBC and advanced stage breast cancer.
|
29874851 |
2018 |