|
Ulcerative Colitis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Thus, F. nucleatum orchestrates a molecular network involving CARD3 and IL-17F to control the UC process.
|
31610014 |
2020 |
|
Ulcerative Colitis
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
The present study was aimed at describing expression of innate immunity genes (NOD2, RIP2, α-defensins HD5 and HD6) in inflamed colon and in ileum of children with ulcerative colitis.
|
20452301 |
2010 |
|
Ulcerative Colitis
|
0.320 |
Biomarker
|
disease |
CTD_human |
The present study was aimed at describing expression of innate immunity genes (NOD2, RIP2, α-defensins HD5 and HD6) in inflamed colon and in ileum of children with ulcerative colitis.
|
20452301 |
2010 |
|
Leprosy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
|
22019778 |
2011 |
|
Leprosy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genomewide association study of leprosy.
|
20018961 |
2009 |
|
Leprosy
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide association study of leprosy.
|
20018961 |
2009 |
|
Inflammatory disorder
|
0.040 |
Biomarker
|
group |
BEFREE |
Genetic loss or pharmaceutical inhibition of RIP2 has been shown to be beneficial in multiple inflammatory disease models with the effects largely attributed to reducing proinflammatory signaling downstream of peptidoglycan recognition.
|
31113864 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Monotherapy with CCKR blockade significantly decreased tumor size and metastases in SCID mice with orthotopic PDAC, and in C57BL/6 mice, it reduced fibrosis and induced the influx of TILs.
|
29043413 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Inflammatory disorder
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Further we show a second allele of RIPK2 linked to an inflammatory disease associated with arthritis also has enhanced activity stimulating the NF-κB pathway.
|
29659823 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
A xenograft mouse model was used to assess tumor growth and chemosensitivity to docetaxel in vivo in MDA-MB-231 cells with and without RIP2 small hairpin RNA knockdown.
|
24642040 |
2014 |
|
Inflammatory disorder
|
0.040 |
Biomarker
|
group |
BEFREE |
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
|
25213858 |
2014 |
|
Inflammatory disorder
|
0.040 |
Biomarker
|
group |
BEFREE |
This article reviews the role that the NOD2:RIP2 complex plays in inflammatory disease, with an emphasis on the inhibition of this signaling pathway as a novel pharmaceutical target in inflammatory disease.
|
23794710 |
2013 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Receptor-interacting serine/threonine protein kinase-2 (RIPK2) has been reported to be an important regulator of tumor proliferation, differentiation and wound repair.
|
22993319 |
2012 |
|
Bacterial Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Furthermore, the expression of zebrafish histone H2A was decreased by RIP2 deficiency with and/or without bacterial infection.
|
31336107 |
2019 |
|
Bacterial Infections
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The results showed that NOD1 can identify LPS and activate the NF-κB signal pathway by recruiting RIPK2 and then promoting the expression of inflammatory cytokines to induce the resistance of organism against bacterial infection.
|
30013548 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Indeed, we can demonstrate that RIPK2 activity correlated with advanced tumor, metastasis, and group stage as well as body mass index (BMI) to indicate that RIPK2 might be a useful prognostic marker for IBC and advanced stage breast cancer.
|
29874851 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Bacterial Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Collectively, these findings demonstrate that NOD1 detects PG within early endosomes, thereby promoting RIP2-dependent autophagy and inflammatory signaling in response to bacterial infection.
|
24746552 |
2014 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A total of six breast cancer expression databases, including The Cancer Genome Atlas, were assessed for RIP2 expression among various clinical subtypes and its role as a prognostic biomarker. mRNA fluorescence in situ hybridization (FISH) for RIP2 was performed on 17 stage III breast cancers to determine if there was a correlation between RIP2 expression and lymph node involvement.
|
24642040 |
2014 |
|
Crohn Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Using these markers and the FDA-approved RIPK2 inhibitor Gefitinib, we show that pharmacologic RIPK2 inhibition drastically improves disease in a spontaneous model of Crohn Disease-like ileitis.
|
25213858 |
2014 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These results highlight RIP2 as a pro-metastasis kinase in patients with advanced breast cancer.
|
24642040 |
2014 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
A total of six breast cancer expression databases, including The Cancer Genome Atlas, were assessed for RIP2 expression among various clinical subtypes and its role as a prognostic biomarker. mRNA fluorescence in situ hybridization (FISH) for RIP2 was performed on 17 stage III breast cancers to determine if there was a correlation between RIP2 expression and lymph node involvement.
|
24642040 |
2014 |