|
Acromegaly
|
0.030 |
Biomarker
|
disease |
BEFREE |
Despite of the key role of SOCS2 in the regulation of GH receptor signaling, we did not find any significant association between SOCS2 polymorphisms and acromegaly.
|
27900634 |
2017 |
|
Acromegaly
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To evaluate whether variations in SOCS2 expression in the colonic mucosa of acromegalic patients might be associated to hyperplastic polyps, patients with active acromegaly or disease in remission with or without hyperplastic polyps were studied; controls were non-acromegalic subjects age- and sex- matched with or without polyps.
|
18844680 |
2009 |
|
Acromegaly
|
0.030 |
Biomarker
|
disease |
BEFREE |
Suppressor of cytokine signaling (SOCS) 2, a negative regulator of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), which is associated with acromegaly and cancers, is a promising candidate molecule for treating various diseases.
|
30343638 |
2019 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias.
|
25858143 |
2015 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness.
|
31235852 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, our results reveal an important role for SOCS2 dysregulation in the pathogenicity of lung adenocarcinoma, suggest its potential use as a biomarker for diagnosing lung adenocarcinoma, and paves the way to develop novel therapy targets as the axis of SOCS2-IGF1R-STAT in lung adenocarcinoma.
|
29559623 |
2018 |
|
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed that SOCS2 protein levels assayed by immunohistochemistry are elevated in hormone therapy-naive localized prostatic adenocarcinoma in comparison with benign tissue.
|
24031028 |
2014 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.
|
29171881 |
2018 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although, the expression of key SOCS genes did not change to a large extent as a result of AD pathology, there were significantly increased levels of SOCS-2, SOCS-3 and CIS mRNA and increased protein levels of SOCS-4 and SOCS-7 in AD brains.
|
25286386 |
2015 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.
|
27330188 |
2016 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Defining the role of common variation in the genomic and biological architecture of adult human height.
|
25282103 |
2014 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Many sequence variants affecting diversity of adult human height.
|
18391951 |
2008 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Further, functional validation of estrogen:miR-191:SATB1 link suggests a cascade initiated by estrogen that induces miR-191 in ER-dependent manner to target SATB1, a global chromatin remodeler, thereby contributing to estrogen-specific gene signature to regulate genes like ANXA1, PIWIL2, CASP4, ESR1/ESR2, PLAC1 and SOCS2 involved in breast cancer progression and migration.
|
23542418 |
2013 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
SOCS-2 protein was expressed in 34 of 50 breast carcinoma samples and was positively associated with low grade, low nuclear grade, and p27 protein.
|
16189149 |
2005 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The SOCS1 and SOCS2 expression levels had the best specificity and sensitivity values respectively for breast cancer diagnosis.
|
30453988 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Favorable prognostic value of SOCS2 and IGF-I in breast cancer.
|
17651480 |
2007 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
SOCS2 (one of three SNPs) and all STAT3, STAT5A, and STAT5B SNPs significantly interacted with use of aspirin/NSAIDs to alter breast cancer-specific mortality.
|
25104439 |
2014 |
|
Candidiasis of vagina
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protective Effects of cis-2-Dodecenoic Acid in an Experimental Mouse Model of Vaginal Candidiasis.
|
30558702 |
2018 |
|
Candidiasis, Vulvovaginal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protective Effects of cis-2-Dodecenoic Acid in an Experimental Mouse Model of Vaginal Candidiasis.
|
30558702 |
2018 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family and influences the carcinogenesis of multiple types of tumors, but the biological roles of SOCS2 in HCC remain unclear.
|
27465557 |
2016 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2.
|
25561270 |
2015 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Analysis based on TCGA database indicated that NR1H4 and SOCS2 were downregulated in liver cancer, this suggest NR1H4 and SOCS2 may play an important role in tumorigenesis.
|
30787420 |
2019 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Suppressor of cytokine signaling 2 (SOCS2) is a key regulator of the GH, IGF, and prolactin signaling pathways that have been implicated in carcinogenesis.
|
24280133 |
2014 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This is the first report on the favorable prognostic value of high SOCS2 expression in primary mammary carcinomas.
|
17651480 |
2007 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
A herpes simplex virus type 2-encoded microRNA promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer.
|
28468588 |
2017 |