|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
The expressions of miR-196a, miR-196b and suppressor of cytokine signaling 2 (SOCS2) were measured in HCC tissues and cells by quantitative real-time polymerase chain reaction or immunohistochemistry.
|
30988277 |
2019 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our study demonstrated that SOCS2 inhibited human HCC metastasis, and SOCS2 might provide a new potential therapeutic strategy for treating HCC.
|
27465557 |
2016 |
|
Liver carcinoma
|
0.340 |
PosttranslationalModification
|
disease |
BEFREE |
Hypermethylation of SOCS2-7 and CISH genes was seldom found in HCC.
|
23941364 |
2014 |
|
Liver carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrate for the first time that SOCS2 and SOCS6 expression were remarkably reduced in HCC and may be served as potential prognostic markers for patients with this deadly disease.
|
23475171 |
2013 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
PSYGENET |
The present study aimed to determine the behavioural phenotype of transgenic mice over-expressing SOCS2 (SOCS2 Tg) in paradigms of relevance to schizophrenia.
|
25283341 |
2015 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Narcolepsy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain.
|
17521418 |
2007 |
|
Narcolepsy-Cataplexy Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain.
|
17521418 |
2007 |
|
Dermatitis, Allergic Contact
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene transcripts as potential diagnostic markers for allergic contact dermatitis.
|
16033404 |
2005 |
|
Sepsis
|
0.200 |
Biomarker
|
disease |
RGD |
Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation.
|
12644450 |
2003 |
|
Lean body mass
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.
|
30593698 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Defining the role of common variation in the genomic and biological architecture of adult human height.
|
25282103 |
2014 |
|
Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.
|
21194676 |
2011 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Many sequence variants affecting diversity of adult human height.
|
18391951 |
2008 |
|
Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Many sequence variants affecting diversity of adult human height.
|
18391951 |
2008 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
This study demonstrated that miR-492 was over-expressed in PCa and exerted tumor-promoting function in PCa cells via repressing SOCS2 expression.
|
30779065 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Alterations in the p53-SOCS2 axis contribute to tumor growth in colon cancer.
|
29622769 |
2018 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Here, we show that SOCS2 were significantly downregulated in tumour foci in NSCLC patients.
|
29559623 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family and influences the carcinogenesis of multiple types of tumors, but the biological roles of SOCS2 in HCC remain unclear.
|
27465557 |
2016 |
|
Neoplasms
|
0.090 |
PosttranslationalModification
|
group |
BEFREE |
We demonstrate a different methylation pattern within the SOCS2 promoter between tumour tissue and normal control tissue in 25% of CRC patients.
|
25025962 |
2014 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2) as mediator of the cross talk between androgens and GH signals in the prostate and its potential role as tumor suppressor in prostate cancer (PCa).
|
24031028 |
2014 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
The expression levels of SOCS2 and SOCS6 mRNA and protein in tumor, para-tumor and normal liver tissues were detected in 106 HCC patients by real-time quantitative RT-PCR (qRT-PCR) and Western blot.
|
23475171 |
2013 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Cytokine independence correlated with low expression and cytokine dependence with high expression of the JAK/STAT pathway inhibitor suppressor of cytokine signaling 2 (SOCS2) suggesting a two-step mechanism for cytokine independence of MPD cells: (i) activation of the oncogene JAK2V617F and (ii) inactivation of the tumor suppressor gene SOCS2.
|
18769447 |
2008 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The significant correlation seen between SOCS-2 expression, grade, nuclear grade, p27, Ki-67, cyclin A, pRb, and EGFR labelling strongly supports the hypothesis that SOCS-2 loss might be related to cell proliferation and tumour growth in breast carcinoma.
|
16189149 |
2005 |