|
Hodgkin Disease
|
0.360 |
Biomarker
|
disease |
CTD_human |
Tissue microarray analysis of primary Hodgkin lymphomas displayed that 82% cases (95/116) expressed cFLIP in Reed-Sternberg cells.
|
17659339 |
2008 |
|
Hodgkin Disease
|
0.360 |
Biomarker
|
disease |
BEFREE |
Both ATM and FLIP are aberrantly regulated in Hodgkin lymphoma.
|
17932249 |
2008 |
|
Hodgkin Disease
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Tissue microarray analysis of primary Hodgkin lymphomas displayed that 82% cases (95/116) expressed cFLIP in Reed-Sternberg cells.
|
17659339 |
2008 |
|
Hodgkin Disease
|
0.360 |
Biomarker
|
disease |
BEFREE |
In this review, the role of cellular FLICE-like inhibitory protein in the pathogenesis of Hodgkin's lymphoma will be explored and also the possibility of targeting this molecule in order to provide an alternative and potentially safe approach to the treatment of Hodgkin's lymphoma will be investigated.
|
16761935 |
2006 |
|
Hodgkin Disease
|
0.360 |
Biomarker
|
disease |
LHGDN |
The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.
|
16441226 |
2006 |
|
Hodgkin Disease
|
0.360 |
AlteredExpression
|
disease |
LHGDN |
In conclusion, we detected c-FLIP in a significantly lower proportion of nodular lymphocyte-predominant Hodgkin lymphoma cases compared with classic Hodgkin lymphoma cases.
|
15354734 |
2004 |
|
Hodgkin Disease
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
However, strong c-FLIP expression in nodular lymphocyte-predominant Hodgkin lymphoma was associated with transformation to large B-cell lymphoma in 2 cases. c-FLIP expression is not limited to Hodgkin lymphoma, because the majority of diffuse large B-cell lymphoma cases tested were strongly c-FLIP-positive.
|
15354734 |
2004 |
|
Hodgkin Disease
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In one of the two cases with loss of heterozygosity a hemizygous mutation was detected in exon 9. c-FLIP expression was observed in all HL cell lines and in RS cells of all HL cases.
|
12507887 |
2003 |
|
Adult Hodgkin Lymphoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies.
|
17659339 |
2008 |
|
Adult Hodgkin Lymphoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies.
|
17659339 |
2008 |
|
Adult Hodgkin Lymphoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Both ATM and FLIP are aberrantly regulated in Hodgkin lymphoma.
|
17932249 |
2008 |
|
Adult Hodgkin Lymphoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
In this review, the role of cellular FLICE-like inhibitory protein in the pathogenesis of Hodgkin's lymphoma will be explored and also the possibility of targeting this molecule in order to provide an alternative and potentially safe approach to the treatment of Hodgkin's lymphoma will be investigated.
|
16761935 |
2006 |
|
Adult Hodgkin Lymphoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
However, strong c-FLIP expression in nodular lymphocyte-predominant Hodgkin lymphoma was associated with transformation to large B-cell lymphoma in 2 cases. c-FLIP expression is not limited to Hodgkin lymphoma, because the majority of diffuse large B-cell lymphoma cases tested were strongly c-FLIP-positive.
|
15354734 |
2004 |
|
Adult Hodgkin Lymphoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In one of the two cases with loss of heterozygosity a hemizygous mutation was detected in exon 9. c-FLIP expression was observed in all HL cell lines and in RS cells of all HL cases.
|
12507887 |
2003 |
|
Malignant neoplasm of pancreas
|
0.320 |
Biomarker
|
disease |
CTD_human |
Here, the role of c-FLIP in the regulation of death receptor-mediated apoptosis in pancreatic cancer was investigated.
|
20876774 |
2011 |
|
Malignant neoplasm of pancreas
|
0.320 |
Biomarker
|
disease |
BEFREE |
Here, the role of c-FLIP in the regulation of death receptor-mediated apoptosis in pancreatic cancer was investigated.
|
20876774 |
2011 |
|
Malignant neoplasm of pancreas
|
0.320 |
Biomarker
|
disease |
BEFREE |
Overexpression of cellular FLICE-like inhibitory protein (cFLIP) is reported to confer chemoresistance in pancreatic cancer (PaC) cells.
|
19176377 |
2009 |
|
leukemia
|
0.320 |
Biomarker
|
disease |
LHGDN |
Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis.
|
17646662 |
2007 |
|
MYELODYSPLASTIC SYNDROME
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Increased levels of FLIP(SHORT) in RAEB and AML may be related to apoptosis resistance in these diseases and to MDS progression.
|
17270269 |
2007 |
|
MYELODYSPLASTIC SYNDROME
|
0.320 |
Biomarker
|
group |
CTD_human |
NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs).
|
16105982 |
2005 |
|
leukemia
|
0.320 |
Biomarker
|
disease |
CTD_human |
A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells.
|
12970779 |
2003 |
|
leukemia
|
0.320 |
AlteredExpression
|
disease |
LHGDN |
Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation.
|
12592338 |
2003 |
|
MYELODYSPLASTIC SYNDROME
|
0.320 |
AlteredExpression
|
group |
BEFREE |
FLIP(Short) RNA expression was higher in MDS patients than in normal controls in both BMMNC (P=0.03) and CD34+ cells (P=0.08).
|
14562111 |
2003 |
|
MYELODYSPLASTIC SYNDROME
|
0.320 |
AlteredExpression
|
group |
LHGDN |
FLIP(Short) RNA expression was higher in MDS patients than in normal controls in both BMMNC (P=0.03) and CD34+ cells (P=0.08).
|
14562111 |
2003 |
|
Nodular Lymphocyte Predominant Hodgkin Lymphoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies.
|
17659339 |
2008 |