KSR1, kinase suppressor of ras 1, 8844

N. diseases: 42; N. variants: 6
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.040 GeneticVariation disease BEFREE From those findings we evaluated the clinical impact of KSR1 variants in patients with ERα+ BC treated with TAM. 25287073 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.040 AlteredExpression disease BEFREE Moreover, high KSR1 expression, as well as high abundance of these proteins, is correlated with better survival in breast cancer patients who underwent chemotherapy. 26022350 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.040 GeneticVariation disease BEFREE Breast cancer patients (n>1000) with high KSR1 showed better disease-free and overall survival, results also supported by Oncomine analyses, microarray data (n=2878) and genomic data from paired tumor and cell-free DNA samples revealing loss of heterozygosity. 24909178 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.040 Biomarker disease BEFREE In vitro luciferase assays, co-immunoprecipitation as well as western blotting experiments were performed to further study the function of KSR1 in breast cancer. 24129246 2013