|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that schizophrenia is associated with alterations in inhibitory inputs from SST/NPY-containing and CCK-containing subpopulations of GABA neurons and in the signaling via certain GABA(A) receptors that mediate synaptic (phasic) or extrasynaptic (tonic) inhibition.
|
17471287 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients.
|
20732371 |
2010 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder.
|
9491815 |
1998 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cholecystokinin A receptors (CCKAR) modulate CCK-stimulated dopamine release, and mutations in the CCKAR gene may predispose affected individuals to schizophrenia.
|
11549403 |
2001 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia.
|
11443535 |
2001 |
|
Pancreatitis
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
This reduced basolateral exocytosis in part explained the less severe pancreatitis observed in Munc18c<sup>+/-</sup> mice after hyperstimulation with the CCK-8 analog caerulein.
|
29284677 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
No association between C-45T polymorphism in the Sp1 binding site of the promoter region of the cholecystokinin gene and alcoholism.
|
10220011 |
1999 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
We previously reported genetic variations in the promoter and coding regions of the CCKA receptor (CCKAR), CCKBR, and CCK genes and a possible association between polymorphisms of the CCKAR gene and alcoholism.
|
12198366 |
2002 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
A new genetic variant in the Sp1 binding cis-element of cholecystokinin gene promoter region and relationship to alcoholism.
|
9622381 |
1998 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that CCK -45C>T and CCKBR Val125Ile polymorphisms do not have a major role in alcohol dependence in the population studied.
|
11368834 |
2001 |
|
Alcohol withdrawal syndrome
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the genetic variant -45 C to T substitution of the CCK gene promoter region among 195 healthy Japanese and 174 patients with alcohol withdrawal syndrome (52 delirium tremens, 39 hallucinosis, 20 seizures, and 92 lack of these symptoms) by using polymerase chain reaction-based single-strand conformational polymorphism analysis.
|
10235270 |
1999 |
|
Alcohol withdrawal syndrome
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism of the CCK gene in patients with alcohol withdrawal symptoms.
|
10803770 |
2000 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No variants in CCK were associated with panic but broader anxiety phenotypes did show associations.
|
21978736 |
2012 |
|
Anxiety Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
No variants in CCK were associated with panic but broader anxiety phenotypes did show associations.
|
21978736 |
2012 |
|
Body mass index procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
|
22344221 |
2012 |
|
Body mass index procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
|
24348519 |
2013 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three genes cholecystokinin (CCK), GHRL, and LEPR were significantly associated with breast cancer-specific mortality among women with low NA ancestry (P(ARTP) = 0.046,0.015, and 0.046, respectively), while neuropeptide Y (NPY) was significantly associated with breast cancer-specific mortality among women with higher NA ancestry(P(ARTP) = 0.038).BMI did not modify these associations.
|
26472474 |
2016 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
EC: Endometrial cancer; 3'-UTR: 3'-untranslated regions; TPX2: target protein for Xenopus kinesin-like protein 2; TCGA: the Cancer Genome Atlas; UCEC: uterine corpus endometrial carcinoma; CCK-8: cell counting kit-8; OD: optical density; FCM: flow cytometry; EMT: epithelial-mesenchymal transition.
|
29888640 |
2018 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effects of miR-1258 on CRC proliferation were evaluated using CCK-8 assays, EdU incorporation, colony formation assays and cell-cycle assays; in vitro and the in vivo effects were investigated using a mouse tumorigenicity model.
|
30144184 |
2018 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The selective pattern of expression, constitutive activity, and trophic action associated with CCK-BRi4sv suggest that this variant may regulate colorectal cancer cell proliferation though a gastrin-independent mechanism.
|
10913157 |
2000 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The in vitro and in vivo function of COMMD10 in CRC was evaluated using CCK-8 proliferation assay, plate colony formation, cell cycle, apoptosis and animal models.
|
28817833 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This chapter will focus on the in vitro methods for identifying miRNAs roles in cell proliferation, invasion, and metastasis in tumor development, which includes CCK-8 assay, Wound Healing assay, and Transwell assay.
|
29435931 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The impacts of miR-204 on BC cell growth and metastasis in vitro were evaluated by both loss-of-function and gain-of-function assays (CCK-8, crystal violet staining, wound healing and transwell assays).
|
31802889 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Cell counting kit-8 (CCK-8) assay and transwell experiment were performed to detect the proliferation rate and metastasis, respectively.
|
29687841 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, beta3 adrenergic receptor gene polymorphism (Try64Arg) and cholecystokinin (CCK)-A receptor (R) gene polymorphism (-81A/G, -128G/T), which are both associated with obesity, were investigated.
|
16362631 |
2006 |