CCK, cholecystokinin, 885

N. diseases: 326; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE <b>Methods:</b> Cell counting kit-8 (CCK-8) assay, combination index (CI) isobologram, flow cytometry, western blot, xenograft tumor models, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and immunochemistry were used in this study. 28382147 2017
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.040 Biomarker disease BEFREE <b>Methods:</b> Several assays including cell counting Kit-8 (CCK-8) assays, colony formation, flow cytometry, immunofluorescence, tumor spheres, and mice model were used to detect the biological function of FoxM1 in NPC. 30416986 2018
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.070 Biomarker disease BEFREE <b>Methods:</b> To detect the effect of SFA gels and its active ingredients, CCK-8 assay and colony assay were used on cervical cancer cells proliferation. 29721044 2018
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.070 Biomarker disease BEFREE <b>Methods:</b> To detect the effect of SFA gels and its active ingredients, CCK-8 assay and colony assay were used on cervical cancer cells proliferation. 29721044 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.070 Biomarker disease BEFREE <b>Methods:</b> To detect the effect of SFA gels and its active ingredients, CCK-8 assay and colony assay were used on cervical cancer cells proliferation. 29721044 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE <i>In vitro</i> experiments including colony formation, Cell Counting Kit-8 (CCK-8), and flow cytometry and <i>in vivo</i> tumorigenesis assay were performed to explore the effects of EXOSC5 on growth of CRC. 31380280 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 Biomarker disease BEFREE <i>In vitro</i> experiments including colony formation, Cell Counting Kit-8 (CCK-8), and flow cytometry and <i>in vivo</i> tumorigenesis assay were performed to explore the effects of EXOSC5 on growth of CRC. 31380280 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Tumors of mice treated with the antisense oligonucleotide for CCK-C were 75% smaller in volume and 83% reduced in weight (P = 0.03) compared with the control tumors. 15502642 2004
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.010 AlteredExpression disease LHGDN PCOS women had a significantly lower meal-related CCK response (p < 0.05) with no association with satiety, as in the controls (r = 0.64). 15624269 2004
CUI: C0017638
Disease: Glioma
Glioma 		0.100 Biomarker disease BEFREE Glioma cell viability was detected by the cell-counting kit-8 (CCK-8) cell counting assay. 24357514 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE HCC cell proliferation and cell cycle were measured by Cell Counting Kit-8 (CCK-8) and flow cytometry analysis, respectively. 29898761 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 Biomarker disease BEFREE Breast cancer cell growth and survival were examined by CCK‑8 and colony formation assay, whilst cell cycle and apoptosis were determined by flow cytometry. 29956731 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 Biomarker disease BEFREE Breast cancer cell growth and survival were examined by CCK‑8 and colony formation assay, whilst cell cycle and apoptosis were determined by flow cytometry. 29956731 2018
CUI: C0028047
Disease: Nicotine withdrawal
Nicotine withdrawal 		0.010 Biomarker disease BEFREE CCK is a satiety neuropeptide.Animal studies have shown that both acute and chronic exposure to nicotine results in weight loss which is associated with an increase in hypothalamic CCK and that CCK antagonists ameliorate symptoms of nicotine withdrawal. 11509018 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Cholecystokinin A receptors (CCKAR) modulate CCK-stimulated dopamine release, and mutations in the CCKAR gene may predispose affected individuals to schizophrenia. 11549403 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Cholecystokinin A receptors (CCKAR) modulate CCK-stimulated dopamine release, and mutations in the CCKAR gene may predispose affected individuals to schizophrenia. 11549403 2001
CUI: C0003467
Disease: Anxiety
Anxiety 		0.100 Biomarker disease BEFREE CCK appears to play an important role in the neurobiology of anxiety and panic disorders (PD) in both humans and animals. 12627462 2003
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.100 Biomarker group BEFREE CCK appears to play an important role in the neurobiology of anxiety and panic disorders (PD) in both humans and animals. 12627462 2003
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.100 Biomarker disease BEFREE CCK appears to play an important role in the neurobiology of anxiety and panic disorders (PD) in both humans and animals. 12627462 2003
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.220 Biomarker phenotype RGD Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. 15647484 2005
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.370 Biomarker disease CTD_human Cholecystokinin (CCK), which induces pancreatitis, stimulates CrkII tyrosine phosphorylation and CrkII protein complexes, raising the possibility it can be important in the acinar cell responses to ROS. 16187300 2006
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.040 AlteredExpression disease BEFREE CCK was overexpressed in Ewing tumors as compared with other pediatric malignancies such as rhabdomyosarcoma and neuroblastoma, with levels close to those detected in normal tissues expressing the highest levels of CCK. 17438102 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE CCK was overexpressed in Ewing tumors as compared with other pediatric malignancies such as rhabdomyosarcoma and neuroblastoma, with levels close to those detected in normal tissues expressing the highest levels of CCK. 17438102 2007
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.020 AlteredExpression disease BEFREE CCK was overexpressed in Ewing tumors as compared with other pediatric malignancies such as rhabdomyosarcoma and neuroblastoma, with levels close to those detected in normal tissues expressing the highest levels of CCK. 17438102 2007
CUI: C0220611
Disease: Childhood Rhabdomyosarcoma
Childhood Rhabdomyosarcoma 		0.020 AlteredExpression disease BEFREE CCK was overexpressed in Ewing tumors as compared with other pediatric malignancies such as rhabdomyosarcoma and neuroblastoma, with levels close to those detected in normal tissues expressing the highest levels of CCK. 17438102 2007