|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All ADC values correlated inversely with tumor cellularity with the strongest correlation between P10, P25 and mean cell count (-0.558).
|
29782920 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Remarkably, concomitant overexpression of a 3'-UTR-truncated form of p35 promoted tumor growth in vivo and cell proliferation, cell-cycle progression, and cell survival in vitro.
|
28640256 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tissue microarray analysis (361 patients) indicated cofilin-1 staining positively correlating with tumor grade and p23 staining with ER positive status; both therefore merit further investigation as potential biomarkers.
|
24106833 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This makes p23 an attractive target for combating tumor cell metastasis in breast cancer patients.
|
22074947 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Data from genetic animal models suggest that in contrast to the central role of IL-12 for tumor immune-surveillance, its close relative IL-23 rather promotes tumor growth.
|
20603238 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reverse transcriptase-polymerase chain reaction analysis of tumor tissue demonstrated peak expression of IL-12 p35 and p40 at 48 h, which persisted up to 7 days.
|
16763609 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we investigated how p23 regulates ER target gene activation and affects tumor growth and progression.
|
16809759 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
One of them, in which the p40 and p35 form a covalent heterodimer and in which each subunit is fused to a molecule of scFv(L19), displays an excellent tumor targeting performance in vivo, as assessed by quantitative biodistribution analysis, and a potent anti-tumor effect, superior to the one of IL12-scFv(L19)-FLAG.
|
16823838 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
By CGH, gains of chromosomal areas 1q23 approximately q24 (three tumors), 7p21 approximately p22 (three tumors), 7q (four tumors), and 19p13 (three tumors), as well as loss of chromosomal segment 9p22 approximately p23 (three tumors), were the most frequently observed imbalances.
|
15949565 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The gene LZTS1 has been mapped to the 8p22 through p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors.
|
12377406 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, retroviral transduction of tumor cells with p35 did not induce drug resistance, as shown by the absence of long-term tumor cell survival or detectable colony formation activity after CPA treatment.
|
12460909 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, IL-12 p35 and IL-12 p40 were only rarely expressed in regressing Burkitt tumors.
|
11358987 |
2001 |