|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis was performed to assess the association between PXR gene polymorphisms and the susceptibility of IBD, Crohn's disease (CD), and ulcerative colitis (UC).
|
28742404 |
2017 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypermethylation of miR-1247 significantly correlates (p = 0.0006) with refractory UC while PAR2 hypermethylation correlates (p = 0.007) with corticosteroid dependence.
|
27096966 |
2016 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PXR A7635G (rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease (OR: 1.34, 95% CI: 1.03-1.75 and OR: 2.49, 95% CI: 1.24-5.03, respectively).
|
21245992 |
2011 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the other PXR/NR1I2 SNPs were associated with UC or CD susceptibility.
|
21830270 |
2011 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rifaximin, a human PXR activator, is in clinical trials for treatment of IBD and has demonstrated efficacy in Crohn's disease and active ulcerative colitis.
|
20627999 |
2010 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
PXR was underexpressed in colonic tissue of 7 out of 11 Crohn disease and in 4 out of 5 patients with ulcerative colitis.
|
19516190 |
2009 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC).
|
19184329 |
2009 |
|
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low intestinal mRNA levels of the pregnane X receptor (PXR) have been linked to low MDR1 mRNA levels in patients with ulcerative colitis (UC).
|
17262809 |
2007 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Three PXR polymorphisms, including the 1 more strongly correlated with IBD risk in the initial study at -25385C/T (rs3814055) and the 6 haplotypes conformed by them, were analyzed in 365 UC and 331 CD patients and compared with 550 ethnically matched controls.
|
17828778 |
2007 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three PXR polymorphisms, including the 1 more strongly correlated with IBD risk in the initial study at -25385C/T (rs3814055) and the 6 haplotypes conformed by them, were analyzed in 365 UC and 331 CD patients and compared with 550 ethnically matched controls.
|
17828778 |
2007 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
These results show that genetic variation in the PXR encoding gene, which has been associated with altered activity of PXR, is strongly associated with susceptibility to IBD, CD, and UC.
|
16472590 |
2006 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results show that genetic variation in the PXR encoding gene, which has been associated with altered activity of PXR, is strongly associated with susceptibility to IBD, CD, and UC.
|
16472590 |
2006 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Messenger RNA expression of ABCB1 (MDR1) and PXR was significantly reduced in the colon of patients with UC but was unaffected in patients with Crohn's disease.
|
15236169 |
2004 |