CCKAR, cholecystokinin A receptor, 886

N. diseases: 62; N. variants: 5
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE The activity of CCK(1)r maintains adequate levels of dopamine and regulates the activity of serotonin neurons of raphe nuclei, which makes CCK(1)r an interesting therapeutic target for the development of adjuvant treatments for schizophrenia, drug addiction, and mood disorders. 28343167 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Our work provided further evidence in support of the CCKAR hypothesis of schizophrenia and also suggested that haplotype-based association analysis may be a powerful approach for identification of allelic heterogeneity of a disease-underlying gene, which is very likely to be attributable to poor replication of an initial finding due to the reduction of sample power and the complexity of genetic architectures. 22825913 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Our work provided further evidence in support of the CCKAR hypothesis of schizophrenia and also suggested that haplotype-based association analysis may be a powerful approach for identification of allelic heterogeneity of a disease-underlying gene, which is very likely to be attributable to poor replication of an initial finding due to the reduction of sample power and the complexity of genetic architectures. 22825913 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Our study strengthens the conclusion that a CCKAR dysfunction could be involved in the aetiology of schizophrenia. 19753663 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE Our study strengthens the conclusion that a CCKAR dysfunction could be involved in the aetiology of schizophrenia. 19753663 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease LHGDN Our data support a possible role of the CCK-AR gene in the vulnerability to schizophrenia in patients with auditory hallucinations, and suggest remarkable allele heterogeneity. 17413443 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE Our data support a possible role of the CCK-AR gene in the vulnerability to schizophrenia in patients with auditory hallucinations, and suggest remarkable allele heterogeneity. 17413443 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE In conclusion, the present results may not provide evidence for the association between the CCK-AR gene and schizophrenia in the Japanese population. 17413452 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET In conclusion, the present results may not provide evidence for the association between the CCK-AR gene and schizophrenia in the Japanese population. 17413452 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Our data support a possible role of the CCK-AR gene in the vulnerability to schizophrenia in patients with auditory hallucinations, and suggest remarkable allele heterogeneity. 17413443 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease LHGDN The aim of this study is to assess the association between AH, using a specific scale for AH in schizophrenia (PSYRATS), and the CCK-AR polymorphism at 779 in a Spanish sample. 15363473 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET The aim of this study is to assess the association between AH, using a specific scale for AH in schizophrenia (PSYRATS), and the CCK-AR polymorphism at 779 in a Spanish sample. 15363473 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE The aim of this study is to assess the association between AH, using a specific scale for AH in schizophrenia (PSYRATS), and the CCK-AR polymorphism at 779 in a Spanish sample. 15363473 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE The results supported our previous data, and suggest the possible involvement of the -333G>T and the -286A>G polymorphisms in the promoter region of the CCKAR gene in the predisposition to schizophrenia. 11549403 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE We speculated that alterations in the CCK-AR lead to an increase in dopamine release, which may in turn constitute a predisposition in schizophrenia. 10893485 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE The present study suggests that the CCK-A receptor gene may be associated with auditory hallucinations in schizophrenia. 10572328 1999