DisGeNET - a database of gene-disease associations

CCKAR, cholecystokinin A receptor, 886

N. diseases: 62; N. variants: 5

Disease: Malignant neoplasm of gallbladder ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0153452
Disease:	Malignant neoplasm of gallbladder

Malignant neoplasm of gallbladder

0.320

AlteredExpression

disease

BEFREE

Significantly higher expression of CCKAR mRNA (P < 0.0001) and protein (P < 0.0001) was observed in GBC tissues.

25025063

2014

CUI:	C0153452
Disease:	Malignant neoplasm of gallbladder

Malignant neoplasm of gallbladder

0.320

Biomarker

disease

CTD_human

Significantly higher expression of CCKAR mRNA (P < 0.0001) and protein (P < 0.0001) was observed in GBC tissues.

25025063

2014

CUI:	C0153452
Disease:	Malignant neoplasm of gallbladder

Malignant neoplasm of gallbladder

0.320

GeneticVariation

disease

BEFREE

These findings suggest that variants in the CCKAR gene may influence the risk of gallbladder cancer in women.

23701593

2013