PER2, period circadian regulator 2, 8864

N. diseases: 238; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3807327
Disease: ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1
ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1 		0.800 Biomarker disease MGD
CUI: C3807327
Disease: ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1
ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1 		0.800 CausalMutation disease CLINVAR
CUI: C1858496
Disease: Advanced Sleep-Phase Syndrome, Familial
Advanced Sleep-Phase Syndrome, Familial 		0.590 Biomarker disease CTD_human
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.450 Biomarker disease HPO
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.390 GeneticVariation disease UNIPROT
CUI: C1833362
Disease: Sleep-wake cycle disturbance
Sleep-wake cycle disturbance 		0.100 Biomarker phenotype HPO
CUI: C4703587
Disease: Early chronotype
Early chronotype 		0.100 Biomarker phenotype HPO
CUI: C1858496
Disease: Advanced Sleep-Phase Syndrome, Familial
Advanced Sleep-Phase Syndrome, Familial 		0.590 GeneticVariation disease BEFREE (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. 17218251 2007
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.010 AlteredExpression group BEFREE IBD activity was determined at baseline and after the follow-up period (2 years or more) using the Harvey-Bradshaw Index for CD and the Simple Clinical Colitis Activity Index for UC (scores ≥5 used to define disease activity). 29366841 2018
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.010 AlteredExpression disease BEFREE IBD activity was determined at baseline and after the follow-up period (2 years or more) using the Harvey-Bradshaw Index for CD and the Simple Clinical Colitis Activity Index for UC (scores ≥5 used to define disease activity). 29366841 2018
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.010 AlteredExpression disease BEFREE Hypothyroidism disrupted the circadian expression pattern of Bmal1 and period circadian regulator 2 (Per2) and decreased the mesor of Nr1d1 and Tef. 30747053 2019
CUI: C0017665
Disease: Membranous glomerulonephritis
Membranous glomerulonephritis 		0.010 Biomarker disease BEFREE Membranous nephropathy and minimal change disease were more frequent in period 2 than in period 1. 31169695 2019
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.040 AlteredExpression group LHGDN Per2 levels were reduced in lymphoma cell lines and in acute myeloid leukemia (AML) patient samples. 15985538 2005
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.040 AlteredExpression group BEFREE Per2 levels were reduced in lymphoma cell lines and in acute myeloid leukemia (AML) patient samples. 15985538 2005
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.030 AlteredExpression disease BEFREE Per2 levels were reduced in lymphoma cell lines and in acute myeloid leukemia (AML) patient samples. 15985538 2005
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma 		0.030 AlteredExpression disease BEFREE Per2 levels were reduced in lymphoma cell lines and in acute myeloid leukemia (AML) patient samples. 15985538 2005
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.020 AlteredExpression disease LHGDN Per2 levels were reduced in lymphoma cell lines and in acute myeloid leukemia (AML) patient samples. 15985538 2005
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.020 AlteredExpression disease BEFREE Per2 levels were reduced in lymphoma cell lines and in acute myeloid leukemia (AML) patient samples. 15985538 2005
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.040 AlteredExpression group BEFREE Per2 mutant (Per2(m/m)) mice show an increase in lymphomas and deregulated expression of cyclin D and c-Myc genes that are key to proliferation control. 19010825 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Per2, a core clock gene with tumour suppresser function, is critical to clock function and to the regulation of cellular proliferation. 19106159 2009
CUI: C0004277
Disease: Tooth Attrition
Tooth Attrition 		0.010 Biomarker disease BEFREE PER2 is implicated in attrition in weight-loss treatment and may modulate eating-behavior-related phenotypes. 20497782 2010
CUI: C1832661
Disease: ANOPHTHALMIA AND PULMONARY HYPOPLASIA
ANOPHTHALMIA AND PULMONARY HYPOPLASIA 		0.020 Biomarker disease BEFREE PER2 expression was highly associated with survival data, thus representing a novel biomarker for earlier detection of PDAC. 24171174 2013
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.030 Biomarker phenotype BEFREE Period 2: an abnormal value after a 2-h 75-g GTT result was diagnostic of GDM. 27022779 2017
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.030 Biomarker group BEFREE Per2, a circadian gene, plays a role in drug addiction. 30091820 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.030 Biomarker disease BEFREE A high percentage of both treatment-experienced (50%) and treatment-naïve (≥ 60%) patients had undetectable HCV-RNA (< 25 IU/mL) after period 2. 20938912 2010