PER2, period circadian regulator 2, 8864

N. diseases: 238; N. variants: 15
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs74508725
rs74508725
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0005890
Disease:
Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs35333999
rs35333999
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0008810
Disease:
Circadian Rhythms
T 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. 26955885 2016
dbSNP: rs121908635
rs121908635
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C3807327
Disease:
ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1
0.700 GeneticVariation UNIPROT An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 11232563 2001
dbSNP: rs1559332542
rs1559332542
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C3807327
Disease:
ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1
A 0.700 CausalMutation CLINVAR
dbSNP: rs76355956
rs76355956
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0393770
Disease:
Delayed Sleep Phase Syndrome
0.010 GeneticVariation BEFREE The p.Val1205Met substitution could be a potential genetic marker for DSWPD. 31527662 2019
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE Moreover, we found an increased risk of estrogen-/progesterone-positive tumors under the dominant genetic model of <i>PER2</i> rs934945 and estrogen negative tumors under the variant genotype of <i>CRY2</i> rs10838524, <i>PER1</i> rs2735611. 31739444 2019
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C2830004
Disease:
Somnolence
0.010 GeneticVariation BEFREE The polymorphisms rs11932595 of the CLOCK gene and rs934945 of the PER2 gene were associated with daytime sleepiness in the patient group. 30818221 2019
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C1261473
Disease:
Sarcoma
0.010 GeneticVariation BEFREE The present analysis suggested that carriers of the minor allele of the CLOCK polymorphism rs1801260 (C) or of PER2 rs934945 (T) had a reduced predisposition to sarcoma (26% and 35% respectively with the additive model) and liposarcoma (33% and 41% respectively). 30518396 2018
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C4551686
Disease:
Malignant neoplasm of soft tissue
0.010 GeneticVariation BEFREE The present analysis suggested that carriers of the minor allele of the CLOCK polymorphism rs1801260 (C) or of PER2 rs934945 (T) had a reduced predisposition to sarcoma (26% and 35% respectively with the additive model) and liposarcoma (33% and 41% respectively). 30518396 2018
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0279984
Disease:
Childhood Liposarcoma
0.010 GeneticVariation BEFREE The present analysis suggested that carriers of the minor allele of the CLOCK polymorphism rs1801260 (C) or of PER2 rs934945 (T) had a reduced predisposition to sarcoma (26% and 35% respectively with the additive model) and liposarcoma (33% and 41% respectively). 30518396 2018
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0023827
Disease:
liposarcoma
0.010 GeneticVariation BEFREE The present analysis suggested that carriers of the minor allele of the CLOCK polymorphism rs1801260 (C) or of PER2 rs934945 (T) had a reduced predisposition to sarcoma (26% and 35% respectively with the additive model) and liposarcoma (33% and 41% respectively). 30518396 2018
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0278608
Disease:
Adult Liposarcoma
0.010 GeneticVariation BEFREE The present analysis suggested that carriers of the minor allele of the CLOCK polymorphism rs1801260 (C) or of PER2 rs934945 (T) had a reduced predisposition to sarcoma (26% and 35% respectively with the additive model) and liposarcoma (33% and 41% respectively). 30518396 2018
dbSNP: rs184017310
rs184017310
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0268490
Disease:
Tyrosinemia, Type I
0.010 GeneticVariation BEFREE Due to a genetic founder effect in the French-Canadian population, the prevalence of HTI is increased in the province of Quebec (1/19 819), with the IVS12 + 5G>A (1062 + 5G>A) splice site mutation responsible for more than 90% of mutated alleles. 28755192 2017
dbSNP: rs2304674
rs2304674
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.010 GeneticVariation BEFREE The rs2304674 SNP demonstrated a significant association with susceptibility to RA following Bonferroni correction. 28498398 2017
dbSNP: rs6754875
rs6754875
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.010 GeneticVariation BEFREE In order to identify the association between genetic polymorphisms in the circadian clock gene period 2 (PER2) and RA, the present study genotyped three PER2 single nucleotide polymorphisms (SNPs), rs934945, rs6754875, and rs2304674, using genetic information from 256 RA patients and 499 control subjects. 28498398 2017
dbSNP: rs934945
rs934945
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.010 GeneticVariation BEFREE In order to identify the association between genetic polymorphisms in the circadian clock gene period 2 (PER2) and RA, the present study genotyped three PER2 single nucleotide polymorphisms (SNPs), rs934945, rs6754875, and rs2304674, using genetic information from 256 RA patients and 499 control subjects. 28498398 2017
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0034067
Disease:
Pulmonary Emphysema
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0027051
Disease:
Myocardial Infarction
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0519066
Disease:
Acute Q fever
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0684249
Disease:
Carcinoma of lung
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0011847
Disease:
Diabetes
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0011849
Disease:
Diabetes Mellitus
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs181985043
rs181985043
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.010 GeneticVariation BEFREE This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers). 27635400 2016
dbSNP: rs10462023
rs10462023
Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0033975
Disease:
Psychotic Disorders
0.010 GeneticVariation BEFREE The rs2290036-C variant of ARNTL was over-represented in psychosis patients, and the variants rs934945-G and rs10462023-G of PER2 were associated with a more severe psychotic disorder. 25799324 2015