PER2, period circadian regulator 2, 8864

N. diseases: 238; N. variants: 15
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 Biomarker phenotype BEFREE During the follow-up period, 2 (3.5%) patients in subsegmentectomy group and 9 (4.1%) patients in segmentectomy group developed distant metastasis. 31672480 2020
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 AlteredExpression phenotype BEFREE Functional studies identified that enhancing Per2 expression in A549 cells by lentivirus transduction not only significantly suppressed cell growth, migration and invasion (P<0.05) but also inhibited NSCLC growth and metastasis in vivo. 30226549 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 GeneticVariation phenotype BEFREE The risk of SCs was higher irrespective of age and it was highest in the period 2-12 months after the diagnosis of CML. 29456888 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 GeneticVariation phenotype BEFREE Within a follow-up period [2-260 months (average 53.5 months)], the local recurrence rate was 15.5%.No patient had metastasis. 28971570 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 AlteredExpression phenotype BEFREE We observed that the levels of circadian protein Per2 were significantly increased and E-cadherin was significantly decreased in the tissue of human esophageal cancer with metastasis as compared with non-metastatic esophageal cancer. 26898709 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 AlteredExpression phenotype BEFREE In addition, Per2 may inhibit the expression of MTA‑1 and promote the expression of nm23‑H1 to restrict ovarian tumor growth and metastasis. 27082164 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 AlteredExpression phenotype BEFREE Pairwise correlations between functionally-related clock genes (e.g., PER2-PER3 and CRY2-PER3) were stronger in ER+, HER2- and low-grade carcinomas; whereas, weaker correlation coefficients were observed in ER- and HER2+ tumors, high-grade tumors and tumors that progressed to metastatic disease. 25485508 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 AlteredExpression phenotype BEFREE These results suggest a role for hPer2 in normal colorectal cell function and the potential deregulation of hPer2 expression in the development, invasion, and metastasis of CRC. 22166120 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 AlteredExpression phenotype BEFREE No patient had topical recurrence or developed metastatic disease during follow-up period (2-13 years, mean time 7.4 years). 15726621 2005