Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, phosphorylation of KHK-A S80 and p62 S28 and nuclear accumulation of Nrf2 are positively correlated in human HCC specimens and with poor prognosis of patients with HCC.
|
31032410 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, a recent study showed that the downregulation of p62 in hepatic stellate cells (HSCs) promotes hepatocellular carcinoma (HCC) development.
|
30793399 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the effects of curcumin on liver inflammation and fibrosis up to the first dysplastic stage of Hepatocellular carcinoma (HCC) induced by Thioacetamide (TAA) in rats and to clarify the effects of curcumin on LC3-II, SQSTM1, and Bcl-2.
|
28611265 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Autophagy-related markers, LC3, Beclin-1, and p62 expression was immunohistochemically assessed in HCC and adjacent non-tumor (ANT) tissues.
|
29961754 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we deeply mined the integrated large-scale datasets from public microarrays and immunohistochemistry to validate the overexpression of BIRC5 and SQSTM1 while down-regulated FOXO1 expression in HCC.
|
29707114 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma.
|
29311600 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HCC involving HBV infection and AFB1 exposure is associated with relatively high risk of tumor recurrence, and this poor prognosis may relate to high P62 expression.
|
28941211 |
2017 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic p62 elevation contributes to HCC development by preventing oncogene-induced senescence and death of cancer-initiating cells and enhancing their proliferation.
|
27404485 |
2016 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High p62 expression is needed for activation of NRF2 and mTORC1, induction of c-Myc, and protection of HCC-initiating cells from oxidative stress-induced death.
|
27211490 |
2016 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we reveal the molecular mechanism of p62/Sqstm1-dependent malignant progression, and suggest that molecular targeting of p62/Sqstm1 represents a potential chemotherapeutic approach against hepatocellular carcinoma (HCC).
|
27345495 |
2016 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared to non-tumor counterpart, phosphorylated p62 was accumulated in HCC (12/30; 40% of patients).
|
27246794 |
2016 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Notably, BafA1 induced caspase-independent cell death in HCC cells by impairing autophagy flux as demonstrated by elevated LC3 conversion and p62/SQSTM1 levels.
|
27845389 |
2016 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Positive p62 staining was found in 20 out of 20 (100%) HCCs and negative staining was observed in 20 out of 20 non-tumor areas and cirrhotic nodules.
|
24369267 |
2014 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a significant correlation between miR-100 downregulation and p62 upregulation was observed in human HCC tissues, suggesting an autophagy-promoting effect of miR-100.
|
25026290 |
2014 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Autophagic flux in HCC cells was analyzed using the expression of LC3BI/II and p62/SQSTM1, GFP-LC3 transfection, and transmission electron microscopy.
|
24287900 |
2013 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The insulin-like growth-factor 2 (IGF2) mRNA binding protein p62 is highly expressed in hepatocellular carcinoma tissue.
|
21145819 |
2011 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene targeting of p62 in an HCC cell line markedly abrogates the anchorage-independent growth, whereas forced expression of p62, but not a Keap1 interaction-defective mutant, resulted in recovery of the growth defect.
|
21482715 |
2011 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently our laboratory identified a cytoplasmic RNA-binding protein p62 which binds to and regulates the expression of IGF II mRNA. p62 was initially shown to be recognized by auto-antibodies in hepatocellular carcinoma (HCC) but now anti-p62 has been described in diverse malignancies. p62 is uniformly expressed in fetal liver and prominently in 33% of HCC nodules, but not detectable in adult liver or normal tissue adjacent to HCC nodules.
|
12118381 |
2002 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The observations show that p62 is developmentally regulated, expressed in fetal, but not in adult liver, and aberrantly expressed in HCC and could be playing a role in abnormal cell proliferation in HCC and cirrhosis by modulating expression of growth factors such as insulin-like growth factor II.
|
11549587 |
2001 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The homologous proteins are: KH domain-containing protein overexpressed in cancer (Koc); zipcode binding protein, a protein which binds to a conserved nucleotide element in chicken beta-actin mRNA (ZBP1); and a protein which binds to a promoter cis element in Xenopus laevis TFIIIA gene (B3). p62 protein is cytoplasmic in location, and autoantibodies were found in 21% of a cohort of HCC patients.
|
10190901 |
1999 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Most HCCs showed enhanced ras p21 and myc p62 expression, as indicated by staining intensity.
|
2548435 |
1989 |