BCL10, BCL10 immune signaling adaptor, 8915

N. diseases: 205; N. variants: 14
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 AlteredExpression disease BEFREE The sensitivity of the MM cell lines to erufosine-induced apoptosis correlated inversely with the Bcl-X(L) expression level. 20177898 2011
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 Biomarker disease BEFREE We have previously shown that the targeted expression of the transgenes c-Myc and Bcl-X(L) in murine plasma cells produces malignancy that displays features of human myeloma, such as localization of tumor cells to the bone marrow and lytic bone lesions. 17483317 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 AlteredExpression disease BEFREE Our findings demonstrate that the enforced expression of Myc and Bcl-X(L) by Ig enhancers with peak activity in plasma cells generates a mouse model of human PCN that recapitulates some features of human multiple myeloma. 15199411 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 GeneticVariation disease BEFREE Lack of BCL10 mutations in multiple myeloma and plasma cell leukemia. 11241793 2001