BCL10, BCL10 immune signaling adaptor, 8915

N. diseases: 205; N. variants: 14
Disease: Solid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 Biomarker phenotype BEFREE DNA amplification of Bcl10 was also found in other solid tumors. 16280327 2006
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 GeneticVariation phenotype BEFREE Initially, mutations in the BCL10 gene were reported to occur at a high frequency in various types of lymphomas and solid tumors. 11372735 2001
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 GeneticVariation phenotype BEFREE The BCL10 gene, recently isolated due to its involvement in the t(1;14)(p22;q32) of mucosa-associated lymphoid tissue B cell non-Hodgkin lymphoma (MALToma), was shown to have frequent somatic mutations and short deletions within the coding region in MALToma and a variety of other lymphomas and solid tumors. 11425462 2001
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 GeneticVariation phenotype BEFREE Previous reports have suggested that the mononucleotide repeats in BCL10 frequently are mutated in both hematologic malignancies and solid tumors. 11180594 2001
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 GeneticVariation phenotype BEFREE In contrast, we detected Bcl10 mutations in 4 of 120 lymphomas (3.3%) and 2 of 78 GCTs (2.6%), respectively, but no mutation was found in the remaining solid tumors analyzed. 10582682 1999