Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the three MALT lymphoma associated chromosome translocations, namely t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;q21)/IGH-MALT1,and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1, are also capable of activating both canonical and non-canonical NF-κB pathways.
|
27452667 |
2016 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both t(11;18)(q21;q21)-positive MALT lymphoma cases and those with nuclear BCL10 expression are considered resistant to H. pylori eradication.
|
22363141 |
2012 |
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Few cases of breast MALT lymphomas in the literature have been assessed for MALT lymphoma-associated translocations and BCL10 expression, underlying their rarity in primary breast MALT lymphomas.
|
22842723 |
2012 |
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As we observed MALT1-API2 to be an efficient target of its own E3 ubiquitin ligase activity, our data suggest that this inherent instability of MALT1-API2 prevents its accumulation and renders a potential effect on MALT lymphoma development via destabilization of BCL10 unlikely.
|
19279678 |
2009 |
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Translocations involving IGH were detected in 36 (32%) of 111 cases; their partner genes included BCL6 (n = 10), c-MYC (n = 5), and FOXP1 (n = 3) but remained unknown in the remaining 18 cases. t(14;18)/IGH-BCL2, t(14;18)/IGH-MALT1, and t(1;14)/BCL10-IGH were not detected in any case. t(11;18)/API2-MALT1 was detected in none of the cases, except for one case of DLBCL with MALT lymphoma, which showed positive signals only in MALT lymphoma cells.
|
18445693 |
2008 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the efficacy of H. pylori eradication and assessed the predictive value of BCL10 nuclear expression and t(11;18)(q21;q21) regarding resistance to H. pylori eradication in primary gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) patients from mainland China.
|
18949449 |
2008 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We assessed the incidence and clinical significance of the MALT lymphoma-associated genetic abnormalities t(11;18)/API2-MALT1, t(1;14)/BCL10-IGH, t(14;18)/IGH-MALT1, t(3;14)/FOXP1-IGH, and extra copies of MALT1 and FOXP1 in gastric MALT lymphomas from Japan.
|
17525089 |
2007 |
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results showed five key findings, which are (a) higher detection rates of t(11;18) (21.13%) in Chinese patients with transformed MALT lymphoma, (b) lower detection rates of t(11;18) in stomach MALT lymphoma, (c) different organ localizations of MALT lymphoma in Chinese patients, (d) higher nuclear expression rates of Bcl-10 in low grade MALT (51.72%), and (e) lower response rates (50% CR, and 50% PR) to anti-H.-pylori therapy.
|
17852708 |
2007 |
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study further supports the close interaction between the MALT1 and BCL10 proteins in the pathogenesis of MALT lymphomas and may indicate that BCL10 immunohistochemistry is a simple technique to identify those MALT lymphoma cases with an underlying genetic aberration.
|
16341151 |
2006 |
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, MALT1 and BCL10 expression was examined in normal lymphoid tissues and 423 cases of MALT lymphoma from eight sites, and their expression was correlated with the above translocations, which were detected by molecular and molecular cytogenetic methods.
|
15682443 |
2005 |
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nuclear BCL10 expression was identified in 58% of MALT lymphoma cases, but not in any DLBCL cases.
|
14674990 |
2004 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Borrelia burgdorferi infection has been suggested as a possible causative agent in European cutaneous cases of marginal zone B-cell lymphoma, whereas API2-MALT1 fusion and BCL10 mutation are highly associated with MALT lymphoma.
|
12883238 |
2003 |
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We therefore screened 51 cases of pulmonary MALT lymphoma for API2-MALT1 fusion, and studied its relationship with clinicopathologic factors including the immunohistochemical expression of BCL10, another MALT lymphoma-associated molecule.
|
12651604 |
2003 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BCL10, a gene involved in the chromosomal translocation t(1;14)(p22;q32) found in mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), has shown mutation in not only MALT lymphomas but also other lymphold tumors.
|
12017308 |
2002 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific molecular events have been associated with the development of MALT lymphoma including t(11;18) and alterations in Bcl-10 protein expression, and these appear to be interlinked.
|
11753078 |
2002 |
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the role of Bcl10 in MALT lymphoma by analyzing its expression, rearrangement and somatic mutation, by immunostaining, reverse transcriptase-polymerase chain reaction (RT-PCR), Southern blot and PCR in 20 cases of MALT lymphoma.
|
11445840 |
2001 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that both t(11;18)(q21;q21) and BCL10 nuclear expression are associated with advanced MALT lymphoma and that their oncogenic activities may be related to each other.(Blood.2001;98:1182-1187)
|
11493468 |
2001 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Another gene involved in the regulation of apoptosis, the BCL10 gene, has been cloned from a MALT lymphoma cytogenetically characterized by the t(1;14)(p22;q32).
|
10797525 |
2000 |
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations within the BCL10 coding region resulting in truncated BCL10 proteins with loss of their proapoptotic function and preservation of their NF-kappaB activating function were detected in MALT lymphoma.
|
10942247 |
2000 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gastrectomy specimens of four MALT lymphoma cases were studied by microdissection and clone-specific polymerase chain reaction (CS-PCR) and of a further case with t(1;14)(p22;q32) by immunohistochemistry for BCL10 protein, which acted as a tumour marker for tumour cells carrying the translocation.
|
11113866 |
2000 |
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
But the role of alterations of both BCL6 and BCL10 genes in the disease progression of low-grade MALT lymphoma require additional study.
|
11120333 |
2000 |
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).
|
10319863 |
1999 |
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Bcl10 expressed in a MALT lymphoma exhibited a frameshift mutation resulting in truncation distal to the CARD.
|
9989495 |
1999 |