|
Hirschsprung Disease
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Consequently, when rs192966556 and rs145882986 alleles of the WNT3A gene lack the SNPs, they are especially associated with a greater risk of HSCR (OR [95% confidence interval]=1.791, p=0.001; OR [95% confidence interval]=1.556, p=0.003, respectively).
|
24817932 |
2014 |
|
Hirschsprung Disease
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
The present study aims to detect the interactions of genetic variations in the WNT3A gene and examine the biological expression levels with Hirschsprung disease (HSCR) in the Chinese people.
|
24817932 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
CTD_human |
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
|
28242765 |
2017 |
|
Reperfusion Injury
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Involvement of the HIF-1α and Wnt/β-catenin pathways in the protective effects of losartan on fatty liver graft with ischaemia/reperfusion injury.
|
23875703 |
2014 |
|
Juvenile osteoporosis
|
0.300 |
SusceptibilityMutation
|
disease |
ORPHANET |
Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis.
|
22789636 |
2012 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
RGD |
Effects of postnatal thyroid hormone deficiency on neurogenesis in the juvenile and adult rat.
|
19233274 |
2009 |
|
Osteoporosis
|
0.110 |
Biomarker
|
disease |
BEFREE |
Focusing on the role of Wnt3a (wingless/integrated 3a), this study was aimed to assess effects of mechanical loading to the spine, using ovariectomized (OVX) mice as a model of osteoporosis.
|
31017804 |
2019 |
|
Osteoporosis
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Birth Weight
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
|
31043758 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Wnt3a as a canonical Wnt ligand is strongly implicated in the etiology and pathology of a number of diseases including cancer.
|
31236761 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that the β-catenin transcriptional activity in EAC is independent of Wnt3a/DKK1 site-of-action and define an oncogenic function for DKK1 in this type of malignancy via distinct activation of Akt-mediated intracellular pathways and independently of Wnt-axis inhibition.
|
30906632 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, restoration of Wnt3a expression partially reversed the tumor suppressor action of miR‑485 in RB cells.
|
30896857 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Next, to clarify the pathway of WNT10B in EVTs, we knock-downed WNT10B using siRNA and activated or inhibited the WNT canonical pathway using an activator (lithium chloride) or inhibitor (FH535, XAV939) with WNT10B addition.<b>Results:</b> WNT3A, 5A, and 10B accelerated the invasion in the EVT lines and isolated primary EVTs.
|
31736372 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Wnt3a blockade improved the capacity of T naïve cells to differentiate into effector cells <i>in vitro</i> However, Wnt3a blockade did not affect the function and phenotype of differentiated, partially exhausted, tumor-infiltrating T cells <i>ex vivo</i> Taken together, our data suggest that Wnt3a blockade halts the capacity of Wnt/β-catenin signaling to inhibit the differentiation of T naïve cells, but it does not restore the dysfunction of differentiated T cells, in the tumor setting.<i>Cancer </i>.
|
30018041 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Indeed, tumor-derived Wnt3a strongly suppressed dendritic cell maturation <i>in vitro</i>, and anti-Wnt3a treatment rescued dendritic cell activities <i>in vivo</i> Our results clarify the function of the Wnt3a/β-catenin pathway in antitumor effector T cells and suggest that Wnt3a neutralization might be a promising immunotherapy for rescuing dendritic cell activities.<i>Cancer </i>.
|
30018042 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the effect was not attributable to the interruption of T-cell-intrinsic β-catenin signaling, because Wnt3a/β-catenin activation correlated with enhanced, not reduced, T-cell effector functions both <i>ex vivo</i> and <i>in vitro</i> Adoptively transferred CD8<sup>+</sup> T cells, not directly exposed to the anti-Wnt3a antibody but infiltrating previously Wnt3a-neutralized tumors, also showed improved functions.
|
30018042 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Wnt3a blockade improved the capacity of T naïve cells to differentiate into effector cells <i>in vitro</i> However, Wnt3a blockade did not affect the function and phenotype of differentiated, partially exhausted, tumor-infiltrating T cells <i>ex vivo</i> Taken together, our data suggest that Wnt3a blockade halts the capacity of Wnt/β-catenin signaling to inhibit the differentiation of T naïve cells, but it does not restore the dysfunction of differentiated T cells, in the tumor setting.<i></i>.
|
30018041 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For this purpose, the profiles (expression/methylation/deletion) of β-catenin, p-β-catenin (Y654), Wnt3a, and APC were studied in disease free normal cervical epithelium (n = 9), adjacent normal cervical epithelium of primary tumors (n = 70), CIN (n = 28), CACX (n = 102) samples, and two CACX cell lines (HeLa and SiHa).
|
29079964 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In summary, the findings of this study, based on competing endogenous RNA (ceRNA) theory, combine new data on the interaction between miR-423-5p and Wnt3a and introduce LINC01606 as a new focus for research, thus providing new insight into possible molecular-level approaches to preventing the migration and invasion of GC.
|
30142387 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Multivariate analysis by Cox proportional hazard model showed the association between pN (HR=3.539, P=0.001), venous invasion (HR=2.798, P=0.012), Wnt3a expression (HR=1.691, P=0.046) and overall survival (OS).
|
29435043 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Proprotein convertase subtilisin/kexin type 6 activates the extracellular signal-regulated kinase 1/2 and Wnt family member 3A pathways and promotes <i>in vitro</i> proliferation, migration and invasion of breast cancer MDA-MB-231 cells.
|
29928395 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Wnt3a is involved in the development and metastasis of many malignant tumours.
|
28902357 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings highlight TBX2 as a novel therapeutic target upstream of WNT3A, where WNT3A antagonists could be novel agents for the treatment of metastasis and for skeletal complications in prostate cancer patients.<i>Cancer Res; 77(6); 1331-44.©2017 AACR</i>.
|
28108510 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we found that Wnt3a and its target gene c‑Myc showed higher expression in tumour tissues than normal liver tissues in HCC patients; 71.8% of the cases studied had high Wnt3a and c‑Myc expression levels (n=32); Wnt3a expression positively correlated with its target genes MMP‑7 and c‑Myc.
|
28902357 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Therefore, Wnt3a expression was silenced with siRNA, and then, MTT, flow cytometry, wound healing and Transwell assays were performed to analyse cell proliferation, cycle, migration and invasion.
|
28902357 |
2017 |