|
Malignant neoplasm of ovary
|
0.600 |
Biomarker
|
disease |
BEFREE |
Boosting the apoptotic response of high-grade serous ovarian cancers with CCNE1 amplification to paclitaxel in vitro by targeting APC/C and the pro-survival protein MCL-1.
|
31286496 |
2020 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, knockdown of cyclin E1 in LINC00470-overexpressed cells abolished its promotive effects on HCC cell proliferation.
|
31612313 |
2020 |
|
ovarian neoplasm
|
0.600 |
Biomarker
|
disease |
BEFREE |
From TCGA database, we found that polyamine metabolism was significantly enriched in Cyclin E1-driven OvCa.
|
31657115 |
2019 |
|
ovarian neoplasm
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our finding indicates that miR-107 serves as a tumor suppressor by decreasing CCNE1 expression levels, which may provide potential therapeutic strategies in ovarian cancer treatment.
|
30885433 |
2019 |
|
ovarian neoplasm
|
0.600 |
Biomarker
|
disease |
BEFREE |
Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.
|
31060523 |
2019 |
|
Malignant neoplasm of ovary
|
0.600 |
Biomarker
|
disease |
BEFREE |
From TCGA database, we found that polyamine metabolism was significantly enriched in Cyclin E1-driven OvCa.
|
31657115 |
2019 |
|
Malignant neoplasm of ovary
|
0.600 |
Biomarker
|
disease |
BEFREE |
Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.
|
31060523 |
2019 |
|
Malignant neoplasm of ovary
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our finding indicates that miR-107 serves as a tumor suppressor by decreasing CCNE1 expression levels, which may provide potential therapeutic strategies in ovarian cancer treatment.
|
30885433 |
2019 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The increased risk of HCC in patients with hepatitis B virus or adeno-associated virus type 2 infection might involve activation of cyclin E1 and its effects on chromosomes and genomes of liver cells.
|
30878468 |
2019 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression.
|
31349793 |
2019 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In general, CCAT1 regulate the expression of CCNE1 by acting as a ceRNA to sponge miR-30c-2-3p in regulating the cell proliferation of HCC.
|
30773676 |
2019 |
|
ovarian neoplasm
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes.
|
30209015 |
2018 |
|
Malignant neoplasm of ovary
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
19q12 amplified and non-amplified subsets of high grade serous ovarian cancer with overexpression of cyclin E1 differ in their molecular drivers and clinical outcomes.
|
30209015 |
2018 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Ectopic BTG2 overexpression decreased HCC growth, caused cell cycle arrest at the G1 phase, and downregulated Cyclin D1 and Cyclin E1 protein expression.
|
29441724 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Importantly, CcnE1-driven HCC initiation was dependent on Cdk2.
|
30150405 |
2018 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The cyclin E1 gene represents the site of recurrent integration of the hepatitis B virus in the pathogenesis of hepatocellular carcinoma, and this event is associated with strong up-regulation of cyclin E1 expression.
|
29339491 |
2018 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In aged NEMO<sup>Δhepa</sup> mice, loss of CcnE1 resulted in significant reduction of liver tumorigenesis, while deletion of CcnE2 had no effect on HCC formation.
|
29551768 |
2018 |
|
ovarian neoplasm
|
0.600 |
Biomarker
|
disease |
BEFREE |
Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.
|
27663592 |
2017 |
|
Malignant neoplasm of ovary
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, amplification of CCNE1 was found to be another major factor in HGSOC tumorigenesis, accounting for approximately 20% of all cases.
|
27898521 |
2017 |
|
Malignant neoplasm of ovary
|
0.600 |
Biomarker
|
disease |
BEFREE |
Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.
|
27663592 |
2017 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression.
|
27351279 |
2016 |
|
Malignant neoplasm of ovary
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Histo-genomic stratification reveals the frequent amplification/overexpression of CCNE1 and BRD4 genes in non-BRCAness high grade ovarian carcinoma.
|
25892415 |
2015 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We identified cyclin E1 as a new target of NF90 and found a significant correlation between NF90 and cyclin E1 expression in HCC.
|
25399696 |
2015 |
|
Malignant neoplasm of ovary
|
0.600 |
Biomarker
|
disease |
BEFREE |
Prompted by recent genomic analyses that identified cyclin E1 (CCNE1) gene amplification as a candidate oncogenic driver in high-grade serous ovarian carcinoma, we evaluated the functional role of cyclin E1 in serous carcinogenesis.
|
24366882 |
2014 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that miR-7 exerts tumor-suppressive effects in hepatocarcinogenesis through the suppression of oncogene CCNE1 expression and suggest a therapeutic application of miR-7 in HCC.
|
24370822 |
2014 |