CH25H, cholesterol 25-hydroxylase, 9023

N. diseases: 41; N. variants: 1
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 GeneticVariation disease BEFREE In addition, association analysis of common CH25H variants identified a nominally significant association with MS patients presenting a clinical course consistent with primary progressive disease. 26857497 2016
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 GeneticVariation disease BEFREE We here report, using the MS murine model experimental autoimmune encephalomyelitis (EAE), that Ch25h deletion significantly attenuated EAE disease course by limiting trafficking of pathogenic CD4(+) T lymphocytes to the central nervous system (CNS). 25456971 2015