|
Personality Traits
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Meta-analysis of genome-wide association studies for personality.
|
21173776 |
2012 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Mechanistically, we find that mutp53 augments insulin-induced AKT1 activation by binding and inhibiting the tumor suppressor DAB2IP (DAB2-interacting protein) in the cytoplasm.
|
28667123 |
2017 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The transcription factor Myc-interacting zinc finger protein 1 (Miz-1) can either activate or repress gene expression in concert with binding partners including the Myc oncoprotein in several types of tumors.
|
27109891 |
2016 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The functional interaction of both proteins becomes apparent at oncogenic expression levels of MYC and association with MIZ-1 mediates both oncogenic functions of MYC as well as tumor-suppressive responses to oncogenic levels of MYC.
|
24296348 |
2013 |
|
Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Central neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Childhood Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We found that Miz-1 was highly expressed in favorable NBLs and NLRR3 was induced by Miz-1 expression in NBL cells.
|
21908575 |
2011 |
|
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma.
|
21908575 |
2011 |
|
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma.
|
21908575 |
2011 |
|
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
High MIZ-1 expression was correlated with the small-size neuroblastoma xenografts treated with gene silencing inhibitors or a glucocorticoid.
|
17947461 |
2007 |
|
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
High MIZ-1 expression was correlated with the small-size neuroblastoma xenografts treated with gene silencing inhibitors or a glucocorticoid.
|
17947461 |
2007 |
|
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
High MIZ-1 expression was correlated with the small-size neuroblastoma xenografts treated with gene silencing inhibitors or a glucocorticoid.
|
17947461 |
2007 |
|
Lymphoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models.
|
31273062 |
2019 |
|
Adult Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models.
|
31273062 |
2019 |
|
Childhood Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models.
|
31273062 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The role of MIZ-1 in MYC-dependent tumorigenesis.
|
24296348 |
2013 |
|
Lymphoma
|
0.020 |
Biomarker
|
group |
BEFREE |
The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance.
|
20551174 |
2010 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The Myc protein suppresses the transcription of several cyclin-dependent kinase inhibitors (CKIs) via binding to Miz1; whether this interaction is important for Myc's ability to induce or maintain tumorigenesis is not known.
|
20551174 |
2010 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance.
|
20551174 |
2010 |
|
Childhood Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance.
|
20551174 |
2010 |
|
Decompression Sickness
|
0.010 |
Biomarker
|
disease |
BEFREE |
Asymmetrically induced expression of ARR16 or ARR17 effectively led to root bending in both wild-type and miz1, a previously known hydrotropism-defective mutant.
|
31601978 |
2019 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations suggest that targeting MIZ-1 could render current ALL chemotherapies more effective, with a better outcome for patients.
|
31273062 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations suggest that targeting MIZ-1 could render current ALL chemotherapies more effective, with a better outcome for patients.
|
31273062 |
2019 |