CLDN10, claudin 10, 9071

N. diseases: 62; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4522164
Disease: HELIX SYNDROME
HELIX SYNDROME 		0.610 GeneticVariation disease BEFREE Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome. 28771254 2018
CUI: C4522164
Disease: HELIX SYNDROME
HELIX SYNDROME 		0.610 GeneticVariation disease UNIPROT Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome. 28771254 2018
CUI: C4522164
Disease: HELIX SYNDROME
HELIX SYNDROME 		0.610 GeneticVariation disease UNIPROT Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. 28686597 2017
CUI: C4522164
Disease: HELIX SYNDROME
HELIX SYNDROME 		0.610 Biomarker disease GENOMICS_ENGLAND A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. 19307729 2009
CUI: C4522164
Disease: HELIX SYNDROME
HELIX SYNDROME 		0.610 CausalMutation disease CLINVAR
CUI: C0151714
Disease: Hypermagnesemia
Hypermagnesemia 		0.110 Biomarker disease BEFREE Mice lacking claudin-16 display magnesium and calcium wasting, whereas absence of claudin-10 results in hypermagnesemia and interstitial nephrocalcinosis. 29129401 2018
CUI: C0151714
Disease: Hypermagnesemia
Hypermagnesemia 		0.110 Biomarker disease HPO
CUI: C0373607
Disease: Ferritin measurement
Ferritin measurement 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation? 28334935 2017
CUI: C0696113
Disease: Serum ferritin measurement
Serum ferritin measurement 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation? 28334935 2017
CUI: C0020599
Disease: Hypocalciuria
Hypocalciuria 		0.100 Biomarker phenotype HPO
CUI: C0020620
Disease: Hypohidrosis
Hypohidrosis 		0.100 Biomarker disease HPO
CUI: C0020621
Disease: Hypokalemia
Hypokalemia 		0.100 Biomarker phenotype HPO
CUI: C0032617
Disease: Polyuria
Polyuria 		0.100 Biomarker phenotype HPO
CUI: C0043352
Disease: Xerostomia
Xerostomia 		0.100 Biomarker disease HPO
CUI: C0085602
Disease: Polydipsia
Polydipsia 		0.100 Biomarker phenotype HPO
CUI: C0151908
Disease: Dry skin
Dry skin 		0.100 Biomarker phenotype HPO
CUI: C0231274
Disease: Intolerant of heat
Intolerant of heat 		0.100 Biomarker phenotype HPO
CUI: C0344505
Disease: Alacrima
Alacrima 		0.100 Biomarker disease HPO
CUI: C1522135
Disease: Hypermagnesemia result
Hypermagnesemia result 		0.100 Biomarker phenotype HPO
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.100 Biomarker disease HPO
CUI: C1963094
Disease: Dry Skin, CTCAE
Dry Skin, CTCAE 		0.100 Biomarker phenotype HPO
CUI: C4554647
Disease: Hypermagnesemia, CTCAE
Hypermagnesemia, CTCAE 		0.100 Biomarker phenotype HPO
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 Biomarker phenotype BEFREE <i>In vitro</i>, CLDN10 could promote cellular proliferation, migration, and invasion in PTC cell lines. 30588256 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 AlteredExpression disease BEFREE For instance, Claudin-10(CLDN10) is the high expression in primary hepatocellular carcinoma, papillary thyroid cancer (PTC) and so on. 30588256 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 Biomarker phenotype BEFREE These findings showed that CLDN-10 is functionally involved in hepatocellular carcinoma invasion and is a potential target for hepatocellular carcinoma therapy. 18025272 2007