|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we revealed that Activin A significantly elevated in endometriotic peritoneal fluid and activin receptor-like kinase (ALK4), the specific receptor for Activin A, obviously enhanced in ectopic endometrial MSCs compared with eutopic endometrial MSCs from women with or without endometriosis.
|
31101053 |
2019 |
|
Pulmonary Emphysema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ACVR1B expression levels exhibit a nominally significant association with emphysema distribution.
|
30335480 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that sulforaphane may control the malignant proliferation of CSCs in TNBC via Cripto-mediated pathway by either suppressing its expression and/or by inhibiting Cripto/Alk4 protein complex formation.
|
30679159 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that sulforaphane may control the malignant proliferation of CSCs in TNBC via Cripto-mediated pathway by either suppressing its expression and/or by inhibiting Cripto/Alk4 protein complex formation.
|
30679159 |
2019 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the ALK4/7 receptor blocker SB431542 reversed the promotive effects of Nodal overexpression on bladder cancer cell proliferation, migration, and invasion.
|
30323631 |
2018 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the ALK4/7 receptor blocker SB431542 reversed the promotive effects of Nodal overexpression on bladder cancer cell proliferation, migration, and invasion.
|
30323631 |
2018 |
|
Squamous cell carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report an EML4-ALK4 translocation in a 50-year-old patient with squamous cell carcinoma and an 18 pack-year smoking history.
|
29610932 |
2018 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, ALK4 may be a potential therapeutic target for the treatment of glioma.
|
29278854 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
These results together suggest that the HA-CD44 and activin-A-ALK4 pathways differentially regulate the spheroid formation and maintenance of ALDH<sup>bright</sup> CICs in MM cells, and that both pathways play critical roles in tumor growth in immunodeficient hosts.
|
30061637 |
2018 |
|
Adenocarcinoma of small intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exome data analysis revealed significantly mutated genes previously linked to SBA (TP53, KRAS, APC, SMAD4, and BRAF), recently reported potential driver genes (SOX9, ATM, and ARID2), as well as novel candidate driver genes, such as ACVR2A, ACVR1B, BRCA2, and SMARCA4.
|
29522538 |
2018 |
|
Malignant mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings provide a novel therapeutic option for MM that targets signaling pathways that promote the CIC compartment through CD44 and ALK4.
|
30061637 |
2018 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the ALK4/7 receptor blocker SB431542 reversed the promotive effects of Nodal overexpression on bladder cancer cell proliferation, migration, and invasion.
|
30323631 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
No difference in immunostaining for activin receptor type IB was observed between patients with SRA and those with mild-to-moderate asthma.
|
27807906 |
2017 |
|
ATRIAL ENLARGEMENT
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After angiotensin-II (Ang-II) stimulation which mimicked atrial fibrosis progression, ALK4-deficient mice showed lower expression of ALK4 in atriums, reduced activation of atrial fibroblasts, blunted atrial enlargement and atrial fibrosis, and further reduced AF vulnerability upon right atrial electrophysiological studies as compared to wild-type littermates.
|
28639003 |
2017 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that partial inhibition of ALK4 may reduce MI-induced CF, suggesting ALK4 as a novel target for inhibition of unfavorable CF and for preservation of LV systolic function induced by not only pressure-overload but also MI.
|
28214509 |
2017 |
|
Adenocarcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Human pancreatic ductal adenocarcinomas contain somatic mutations in the activin A receptor type IB (ACVR1B) gene, indicating that ACVR1B could be a suppressor of pancreatic tumorigenesis.
|
26408346 |
2016 |
|
Pancreatic Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors.
|
26408346 |
2016 |
|
Pancreatic Intraductal Papillary Mucinous Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Disruption of Acvr1b in LSL-KRAS(G12D);Pdx1-Cre mice accelerated the growth of pancreatic IPMNs compared with LSL-KRAS(G12D);Pdx1-Cre mice, but did not alter growth of pancreatic intraepithelial neoplasias.
|
26408346 |
2016 |
|
Tumor Angiogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our findings define a regulatory role of miR-98 in tumor angiogenesis and invasion through repressed ALK4 and MMP11 expression.
|
23211491 |
2012 |
|
Seminoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activin type I (ALK2 and ALK4) and type II (ActRIIA and ActRIIB) receptors were detected using immunohistochemistry on Bouins fixed sections of normal, carcinoma in situ (CIS), seminoma, non-seminoma and gonadotropin-deprived human testis.
|
18077314 |
2008 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cripto-1 (CR-1) is an epidermal growth factor (EGF)-CFC protein that has been shown to signal through nodal/Alk-4, PI3K/Akt, and/or ras/raf/MEK/MAPK pathways in mammalian cells, and that is frequently expressed in human primary breast carcinomas.
|
14584041 |
2004 |
|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) demonstrated a significant threefold downregulation of alk4-1 receptors in papillary (n = 25) and follicular (n = 18) thyroid cancers as compared to normal thyroids (n = 12) (p < 0.001).
|
11272093 |
2001 |
|
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) demonstrated a significant threefold downregulation of alk4-1 receptors in papillary (n = 25) and follicular (n = 18) thyroid cancers as compared to normal thyroids (n = 12) (p < 0.001).
|
11272093 |
2001 |
|
Goiter
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Semi-quantitative RT-PCR revealed a significant 2.5-fold decrease of mRNA for alk4-1 type I activin receptors in goiter as compared to normal thyroid (p < 0.05), whereas expression of the type II receptor actRII was unchanged.
|
11069203 |
2000 |
|
Pheochromocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both type I and type II activin receptor (ActR-I, ActR-IB and ActR-II) mRNA expression was also detectable in the pheochromocytoma tissues.
|
10810314 |
2000 |