|
Myocardial Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Elevated levels of activin A in heart failure: potential role in myocardial remodeling.
|
14993131 |
2004 |
|
Pancreatic carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
ACVR1B suppresses early stages of pancreatic tumorigenesis; the activin signaling pathway therefore might be a therapeutic target for pancreatic cancer.
|
26408346 |
2016 |
|
Pancreatic carcinoma
|
0.130 |
PosttranslationalModification
|
disease |
BEFREE |
We identified a homozygous deletion of the ACVR1B gene in PC cell lines and clinical samples and proposed that the deletion of the ACVR1B gene may mediate an aggressive cancer phenotype in PC.
|
24886203 |
2014 |
|
Pancreatic carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer.
|
11248065 |
2001 |
|
Pancreatic carcinoma
|
0.130 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Adenocarcinoma of lung (disorder)
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
When patients were stratified for age, it was found that six of six cases (100%) of lung adenocarcinoma diagnosed in patients <30 years of age were translocated for ALK (4 cases) or ROS1 (2 cases).
|
27237034 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.
|
26732429 |
2016 |
|
Neutrophil count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.
|
26732429 |
2016 |
|
Granulocyte count
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
response to bronchodilator
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The knockdown of CD44 or ALK4 strongly suppressed the tumor growth in immunodeficient mice.
|
30061637 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We have previously discovered that the Activin A ligand acts as a tumor suppressor when epithelial Activin receptor type IB (ACVRIB) is intact; however, this effect is lost upon ACVRIB downregulation.
|
29312797 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In a xenograft study, ACVR1B-knockdown resulted in a significantly elevated level of tumorigenesis and a larger tumor volume, compared with the control.
|
24886203 |
2014 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
To investigate the role of germ-line mutations in the etiology of pancreatic cancer, we have analyzed samples from patients with pancreatic cancer enrolled in the NFPTR for mutations in four tumor suppressor candidate genes: (a) MAP2K4; (b) MADH4; (c) ACVR1B; and (d) BRCA2 by direct sequencing of constitutional DNA.
|
12097290 |
2002 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
ACVR1B has not been described previously as a mutated tumor-suppressor gene.
|
11248065 |
2001 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Three truncated ALK4 receptor mRNAs generated by alternate splicing of the cytoplasmic Ser/Thr kinase domain were found to be tumor specific.
|
8636304 |
1996 |
|
Malignant neoplasm of pancreas
|
0.040 |
Biomarker
|
disease |
BEFREE |
ACVR1B suppresses early stages of pancreatic tumorigenesis; the activin signaling pathway therefore might be a therapeutic target for pancreatic cancer.
|
26408346 |
2016 |
|
Malignant neoplasm of pancreas
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
We identified a homozygous deletion of the ACVR1B gene in PC cell lines and clinical samples and proposed that the deletion of the ACVR1B gene may mediate an aggressive cancer phenotype in PC.
|
24886203 |
2014 |
|
Malignant neoplasm of pancreas
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
No mutations were identified in mitogen-activated protein kinase kinase 4 (0 of 22), MADH4 (0 of 22), or ACVR1B (0 of 29), making it unlikely that germ-line mutations in these genes account for a significant number of inherited pancreatic cancers.
|
12097290 |
2002 |
|
Malignant neoplasm of pancreas
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer.
|
11248065 |
2001 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Aristaless-like homeobox 4 (ALK4) is a member of ALK proteins family and plays an important role in tumorigenesis.
|
29278854 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
STAT3 inhibitor (Niclosamide) obviously enhanced ALK4-inhibted glioma cell proliferation and invasion.
|
29278854 |
2018 |