|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In putative normal DBS specimens from newborns (N=223) C26:0-LPC was 0.09±0.03 μmol/l whole blood, while in peroxisomal biogenesis disorder (including X-ALD) patients (N=28) C26:0-LPC was 1.13±0.67 μmol/l whole blood.
|
22503909 |
2012 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Encapsulating cisplatin (CDDP) into liposomes to form lipid-platinum-chloride nanoparticles (LPC NPs) has shown a promising anticancer effect in melanoma, bladder, and liver cancer models.
|
31810241 |
2019 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
This study aims to investigate the therapeutic effects of intravenous administration of T7 peptide modified core-shell nanoparticles (named T7-LPC/siRNA NPs) on brain tumors.
|
27374198 |
2016 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human breast cancer tumors and cell lines.
|
9185698 |
1997 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggested that T7-LPC/siRNA NPs could be an effective and safe systemic siRNA delivery system for RNAi-based breast cancer therapy.
|
27355138 |
2016 |
|
Cardiovascular Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In addition, mediation tests suggested that a subset of SNPs previously associated with CVD phenotypes in genome-wide association studies may exert their function by altering expression of eQTL genes (eg, LDLR and PCSK7), which in turn may promote interindividual variation in phenotypes.
|
25533967 |
2015 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The decrease in LPC(16:0) in HL and CVD is consistent with its role in regulation of peroxisome proliferator-activated receptor alpha, an approved HL drug target that impacts the uptake and oxidation of fatty acids.
|
28157411 |
2017 |
|
Chronic kidney disease stage 5
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Lasso logistic regression was conducted to identify five final genes, namely, CNOT8, MST4, PPP2CB, PCSK7 and RBBP4 that are differentially expressed and associated with ESKD.
|
31464346 |
2019 |
|
Cirrhosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
MERTK and PCSK7 SNPs were not associated with liver fibrosis or cirrhosis.
|
28338112 |
2017 |
|
Cirrhosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Only variant rs236918 in the PCSK7 gene (proprotein convertase subtilisin/kexin type 7) was associated with cirrhosis or advanced fibrosis (P = 1.02 × 10(-5)) in the German cohort with genotypic odds ratios of 3.56 (95% CI 1.29-9.77) for CG heterozygotes and 5.38 (95% CI 2.39-12.10) for C allele carriers.
|
24556216 |
2014 |
|
Cirrhosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We evaluated PCSK7 alleles and genotypes frequencies according to single or grouped staging scores: absent/mild fibrosis (stage: 0-2), moderate (stage: 3-4), and severe fibrosis/cirrhosis (stage: 5-6).
|
26868056 |
2016 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, it was concluded that LPC-T is an effective carrier for passive targeting of the pulmonary tissue, treatment of Renca-induced pulmonary metastases, and local administration of Renca cell SC tumors.
|
15194050 |
2004 |
|
Coughing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here, we recorded frontal N100, P200, and LPC event-related potentials (ERPs) from 8-month-old infants listening to sounds of other infants crying, laughing, and coughing.
|
29596956 |
2018 |
|
Dermatitis, Atopic
|
0.010 |
Biomarker
|
disease |
BEFREE |
An increase in short-chain LPC species was also observed in nonlesional AD skin.
|
29467325 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our analysis showed that palmitoyl-lysophosphatidylcholine [LPC(16:0)], the most abundant LPC species in normolipidemic plasma, decreases in HL causative conditions such as high-fat diet, obesity, and diabetes.
|
28157411 |
2017 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Our analysis showed that palmitoyl-lysophosphatidylcholine [LPC(16:0)], the most abundant LPC species in normolipidemic plasma, decreases in HL causative conditions such as high-fat diet, obesity, and diabetes.
|
28157411 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Conversely, serine, glutamine and LPC C18:2 decreased risk of T2D.
|
31782507 |
2020 |
|
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
An increase in short-chain LPC species was also observed in nonlesional AD skin.
|
29467325 |
2018 |
|
Fibrosis, Liver
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.
|
24556216 |
2014 |
|
Fibrosis, Liver
|
0.030 |
Biomarker
|
disease |
BEFREE |
MERTK and PCSK7 SNPs were not associated with liver fibrosis or cirrhosis.
|
28338112 |
2017 |
|
Fibrosis, Liver
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We evaluated proprotein convertase 7 (PCSK7) rs236918 as genetic marker of risk of liver fibrosis in an Italian cohort of p.Cys282Tyr homozygotes.
|
26868056 |
2016 |
|
Hemochromatosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings confirm that PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis.
|
26868056 |
2016 |
|
HEMOCHROMATOSIS, TYPE 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings confirm that PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis.
|
26868056 |
2016 |