|
Iron Overload
|
0.010 |
Biomarker
|
disease |
BEFREE |
Proprotein convertase subtilisin/kexin type 7 (<i>PCSK7</i>) gene variation has been associated with circulating lipids and liver damage during iron overload.
|
30918065 |
2019 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Also, in vivo tumor therapy experiments demonstrated that the longest survival period along with the greatest downregulation of EGFR expression in tumor tissues was observed in mice with an intracranial U87 glioma treated with T7-LPC/siEGFR NPs compared with mice receiving other formulations.
|
27374198 |
2016 |
|
Stuttering
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Although the LPC elicited in CWS-eRecovered and CWNS did not differ, the LPC elicited in the CWS-ePersisted was smaller in amplitude compared with that in CWNS.
|
29098269 |
2017 |
|
Leukemogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, our results give evidence of a genomic instability of this area of 11q23 and show that Pafah1a2 and not LPC is the gene disrupted by the translocation, suggesting that deregulated Pafah1a2 may have a role in lymphomagenesis.
|
10362256 |
1999 |
|
Dermatitis, Atopic
|
0.010 |
Biomarker
|
disease |
BEFREE |
An increase in short-chain LPC species was also observed in nonlesional AD skin.
|
29467325 |
2018 |
|
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
An increase in short-chain LPC species was also observed in nonlesional AD skin.
|
29467325 |
2018 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human breast cancer tumors and cell lines.
|
9185698 |
1997 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human breast cancer tumors and cell lines.
|
9185698 |
1997 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
As a first step towards elucidating the role that pro-protein convertases play in the growth regulation of breast cancer, we studied the gene expression of 6 known human convertase members (PC1/PC3, PC2, furin/PACE, PACE4, PC5/PC6 and PC7/LPC) in human breast cancer tumors and cell lines.
|
9185698 |
1997 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
|
24507774 |
2014 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
|
24507774 |
2014 |
|
Pyloric Stenosis, Hypertrophic
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis.
|
22306654 |
2012 |
|
SVEINSSON CHORIORETINAL ATROPHY
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with the control group, the intensities of uric acid, 6,8-dihydroxypurine, hypoxanthine, guanosine, l-phenylalanine, succinyladenosine, tryptophan, lysophosphatidylcholines (LPC(16 : 0), LPC(18 : 1(9z)), LPC(18 : 2(9z,12z))) and inosine in the AA-treated group were significantly increased (p < 0.01); and the intensities of l-acetylcarnitine, 2-phenylacetamide and pantothenic acid in the AA-treated group were decreased (p < 0.01).
|
30379191 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Conversely, serine, glutamine and LPC C18:2 decreased risk of T2D.
|
31782507 |
2020 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Dietary inclusion of LPC increased (P < 0.01) bursa weight and improved (P < 0.05) antibody production titers against sheep red blood cells and Newcastle disease virus during primary responses.
|
27697931 |
2017 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Encapsulating cisplatin (CDDP) into liposomes to form lipid-platinum-chloride nanoparticles (LPC NPs) has shown a promising anticancer effect in melanoma, bladder, and liver cancer models.
|
31810241 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Encapsulating cisplatin (CDDP) into liposomes to form lipid-platinum-chloride nanoparticles (LPC NPs) has shown a promising anticancer effect in melanoma, bladder, and liver cancer models.
|
31810241 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Encapsulating cisplatin (CDDP) into liposomes to form lipid-platinum-chloride nanoparticles (LPC NPs) has shown a promising anticancer effect in melanoma, bladder, and liver cancer models.
|
31810241 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Encapsulating cisplatin (CDDP) into liposomes to form lipid-platinum-chloride nanoparticles (LPC NPs) has shown a promising anticancer effect in melanoma, bladder, and liver cancer models.
|
31810241 |
2019 |
|
Hereditary hemochromatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis.
|
24556216 |
2014 |
|
Psychotic Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Following correction for multiple comparisons, 8 of these lipids remained significant (lysophosphatidlycholines (LPCs) LPC(18:1), LPC(18:2), LPC(20:3); phosphatidlycholines (PCs) PC(32:2; PC(34:2), PC(36:4), PC(0-34-3) and sphingomyelin (SM) SM(d18:1/24:0)), all of which were elevated in the PD group.
|
28949339 |
2017 |
|
Kidney Failure, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Lasso logistic regression was conducted to identify five final genes, namely, CNOT8, MST4, PPP2CB, PCSK7 and RBBP4 that are differentially expressed and associated with ESKD.
|
31464346 |
2019 |