|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The results showed that these four polymorphisms were associated with an increased risk of TB (D543N OR 1.31, 95%CI 1.11-1.55; 3'UTR TGTG ins/del OR 1.45, 95%CI 1.25-1.68; INT4 OR 1.27, 95%CI 1.09-1.49; [GT]n OR 1.35, 95%CI 1.14-1.61).
|
22326178 |
2012 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
NRAMP1 polymorphisms (3'UTR, D543N, INT4) were evaluated among 142 patients with culture-positive pulmonary tuberculosis and 144 ethnically matched healthy controls having latent M. tuberculosis infection.
|
21169917 |
2011 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In Meta-analysis, significant associations were observed between tuberculosis risk and widely studied SLC11A1 polymorphisms with summarized odds ratio of 1.35 (95%CI, 1.17-1.54), 1.25 (95% CI, 1.04-1.50), 1.23 (95% CI, 1.04-1.44), 1.31 (95%CI, 1.08-1.59) for 3' UTR, D543N, INT4, and 5' (GT)n, respectively.
|
21283567 |
2011 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We analysed four NRAMP1 gene polymorphisms including 5' promoter (GT)(n) (rs34448891), INT4 (469 + 14G/C) (rs3731865), 3'UTR (1729 + 55del4) (rs17235416) and rs17235409" genes_norm="6556">D543N (codon 543, Asp to Asn) (rs17235409) in 112 patients with TB, 98 patients with RA, 80 healthy controls for TB and 122 healthy controls for RA using ARMS-PCR and PCR-RFLP.
|
19055603 |
2009 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We did not identify any statistically significant differences between the tuberculosis and control groups with regard to the frequency of genotype variants G/C and C/C at the INT4 locus.
|
19193106 |
2009 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The distribution of three polymorphisms in the natural resistance-associated macrophage protein gene (NRAMP1) including INT4, D543N and 3'UTR was examined for a possible association with susceptibility to TB.
|
17466092 |
2007 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms at the four loci had no statistically significant association between the SLC11A1 variants and susceptibility to TB in subjects of European descent, while they showed a statistically significant association in Asian subjects (except the INT4 variant), African subjects (except the 3'UTR variant) and the population as a whole (except the INT4 variant).
|
16466030 |
2006 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Two NRAMP 1 polymorphisms, INT4 and 5-(CA)n, were significantly associated with susceptibility to tuberculosis in aboriginals (p = 0.0070 and p = 0.0031, respectively).
|
16638645 |
2006 |
|
Tuberculosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
No significant difference in genotype frequency was found between white patients with tuberculosis and control subjects (P>.16), but carriage of Nramp1 variant alleles at loci INT4 and 5'(CA)(n) conferred a significantly increased risk of having microscopy-positive compared with microscopy-negative tuberculosis (65% vs. 35% [P=.0004] and 63% vs. 38% [P=.047], respectively).
|
12195379 |
2002 |