CD19, CD19 molecule, 930

N. diseases: 365; N. variants: 5
Disease: B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4289946
Disease: B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative 		0.010 AlteredExpression disease BEFREE Several approaches have been explored in the past few years including: monoclonal antibodies - either 'naked' (rituximab) or in combination with an immunotoxin (calicheamicin or maytansin), plant toxin (ricin), or bacterial toxin (Pseudomonas or diphtheria), and a novel bispecific T-cell-engaging antibody (blinatumomab); chimeric antigen therapy using autologous T cells that target CD19-expressing ALL; and novel agents such as proteasome inhibitors, liposomal vincristine, hypomethylating agents, nelarabine and NOTCH1 inhibitors. 25471034 2014