ASIC3, acid sensing ion channel subunit 3, 9311

N. diseases: 51; N. variants: 1
Disease: Chronic pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.010 Biomarker phenotype BEFREE Acid-sensing ion channels (ASICs) are extracellular proton-gated cation channels that have been implicated in multiple physiological and pathological processes, and peripheral ASIC3 prominently participate into the pathogenesis of chronic pain, itch, and neuroinflammation, which necessitates the need for discovery and development of novel modulators in a subtype-specific manner. 29781252 2019