|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
The relationship between the expression of mitochondrial fission key regulator dynamin-related protein 1 (Drp1) and the percentage of CD163 (a marker of TAMs)-positive cells was investigated in HCC tissues using immunohistochemistry.
|
30894684 |
2019 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Herein, we measured CYP2E1 activity and the expression of CD163 (an M2 marker) and CD68 (a pan-macrophage marker) in hepatofibrotic tissue from HCC patients (n = 26) with comparison to normal liver tissue (n = 26).
|
31116889 |
2019 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
CTD_human |
Expression levels of macrophage genes (CD68, CD11b, CD206, CD16, CD40, and CD163) were lower in skeletal muscle tissue of obese versus lean participants.
|
29035695 |
2018 |
|
Obesity
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Obesity and T2DM are associated an increased CD68 marker in PBMC. mRNA expression of CD11b, CD11c, CD169, and CD163 were significantly reduced in PBMC from T2DM subjects whereas CD11c was significantly inhibited in PBMC from obese subjects.
|
30356719 |
2018 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
The number of CD163 positive cells was also significantly increased in patients with median tumor size ≥3.5 cm and in those with poorly differentiated HCC.
|
29731831 |
2018 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
<b>Purpose:</b> Hepatocellular carcinoma (HCC) often arises in the setting of chronic liver inflammation and may be responsive to novel immunotherapies.<b>Experimental Design:</b> To characterize the immune microenvironment in HCC, IHC staining was performed for CD8-positive T lymphocytes, PD-1-positive, and LAG-3-positive lymphocytes, CD163-positive macrophages, and PD-L1 expression in tumor and liver background from 29 cases of resected HCC.<b>Results:</b> Expression of CD8 was reduced in tumor, and expression of CD163 was reduced at the tumor interface.
|
28928158 |
2017 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
The IHC results showed that M1 macrophages (CD68+) were present in the para-tumor tissues, while the M2 phenotype (CD163+) was mainly in the HCC tissues.
|
28723685 |
2017 |
|
Obesity
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Soluble CD163 (sCD163) is a new marker of obesity-related metabolic complications. sCD163 and CD163 mRNA were investigated in relation to the fat distribution at baseline and 12 months after Roux-en-Y gastric bypass (RYGB).
|
25376508 |
2015 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Soluble CD163, a marker of macrophage polarization to a proinflammatory profile, was elevated in the obese compared to nonobese children (135 vs 105 ng/mL; P = .03).
|
24423308 |
2014 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Monocytic CD163 was higher in T2D and obesity, whereas sCD163 in the supernatants was not elevated and neither correlated with serum sCD163 nor systemic adiponectin.
|
19490068 |
2009 |
|
Obesity
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our aim was to evaluate the expression of CD163 and HMOX1 in intra-abdominal visceral (omental) and subcutaneous adipose tissue as well as circulating soluble CD163 concentrations in human obesity and its association with adipose tissue inflammation, body fat distribution and insulin resistance.
|
19687791 |
2009 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
BEFREE |
CD163+ perivascular macrophages were identified by immunohistochemistry in brain parenchyma in over 40% of "high inflammation" schizophrenia brains.
|
30214039 |
2018 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
BEFREE |
The upregulation of several of these genes, IFITM1, IFITM2, IFITM3, APOL1 (Apolipoprotein L1), ADORA2A (adenosine receptor 2A), IGFBP4 and CD163 were validated in the schizophrenia subjects using data from the SNCID database and with quantitative RT-PCR.
|
24169640 |
2013 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
The upregulation of several of these genes, IFITM1, IFITM2, IFITM3, APOL1 (Apolipoprotein L1), ADORA2A (adenosine receptor 2A), IGFBP4 and CD163 were validated in the schizophrenia subjects using data from the SNCID database and with quantitative RT-PCR.
|
24169640 |
2013 |
|
Hyperinsulinism
|
0.310 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Hyperinsulinism
|
0.310 |
Biomarker
|
disease |
BEFREE |
Soluble CD14 decreased significantly after stimulation of hyperinsulinemia and no significant changes in soluble CD163 or monocyte chemoattract protein 1 were demonstrated in HIV-infected and non-HIV-infected groups.
|
28514281 |
2017 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Insulin Resistance
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Insulin Sensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Endogenous Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Exogenous Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Compensatory Hyperinsulinemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Hyperglycemia, Postprandial
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
The molecular phenotype of endocapillary proliferation: novel therapeutic targets for IgA nephropathy.
|
25133636 |
2014 |