Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of klotho gene polymorphism and the regulation of calcium-phosphate metabolism disorders in patients with end-stage renal disease.
|
30537427 |
2019 |
Chronic kidney disease stage 5
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In CKD stage 5, creatinine and cFGF23 levels, as well as the cFGF23/Klotho ratio, were higher (P < 0.01), phosphate and iFGF23 levels were higher (P < 0.05), and Klotho levels were lower (P < 0.01), compared with CKD stage 4.
|
30689182 |
2019 |
Chronic kidney disease stage 5
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In light of these findings, the main pathophysiological consequence of the downregulation of Klotho observed in acute and chronic renal failure may be the induction of renal FGF23 resistance.
|
29851418 |
2018 |
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients.
|
29313136 |
2018 |
Chronic kidney disease stage 5
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Klotho levels were higher in AKI patients (567.6 ± 294.4 pg/mL, vs. 403.5 ± 152.5 pg/mL, p < 0.01) and females (463.0 ± 202.6 pg/mL vs. 387.6 ± 132.0 pg/mL, p < 0.01) and lower in ESRD patients than in healthy adults and patients with moderate CKD (368.3 ± 99.0 pg/mL vs. 468.1 ± 205.8, p < 0.01 and 368.3 ± 99.0 pg/mL vs. 498.7 ± 221.9, p < 0.01).
|
28157067 |
2017 |
Chronic kidney disease stage 5
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
The vascular Klotho hypermethylation in radial arteries of patients with end-stage renal disease was described.
|
27766038 |
2016 |
Chronic kidney disease stage 5
|
0.300 |
Biomarker
|
disease |
BEFREE |
We studied 40 patients with CKD on conservative treatment (group A), 44 patients with end-stage renal disease (ESRD) on regular hemodialysis (group B), 40 kidney transplant recipients (KTR) (group C) and 40 healthy controls for measuring serum klotho and FGF-23.
|
25766835 |
2015 |
Chronic kidney disease stage 5
|
0.300 |
Biomarker
|
disease |
BEFREE |
Sequelae of klotho deficiency are similar to those of end-stage renal disease.
|
23298834 |
2013 |
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Regarding the significance of cardiovascular disease for the outcome of ESRD patients, we investigated whether genetic variation of klotho was associated with mortality in ESRD patients on hemodialysis.
|
23993164 |
2013 |
Chronic kidney disease stage 5
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Klotho (KL) expression is down-regulated in the renal tissues of chronic kidney disease (CKD) animal models and patients with end-stage renal disease.
|
24224012 |
2013 |
Chronic kidney disease stage 5
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure.
|
9731228 |
1998 |
Chronic kidney disease stage 5
|
0.300 |
Biomarker
|
disease |
RGD |
This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure.
|
9731228 |
1998 |