Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin (ACRP30), an adipocyte-secreted protein encoded by the APM1 gene, is known to modulate insulin sensitivity and glucose homeostasis, those effects protecting obese mice from diabetes.
|
12354786 |
2002 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27, where the adiponectin gene (APM1) is located.
|
11812766 |
2002 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We measured circulating adiponectin levels and risk factors for atherosclerosis in 45 healthy first-degree relatives of type 2 diabetic subjects (FDR) as well as 40 healthy control subjects (CON) without a known family history of diabetes.
|
12716750 |
2003 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We present genetic analysis of adiponectin levels in 517 Pima Indians without diabetes (from 162 families, 750 sib-pairs).
|
12941784 |
2003 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
Association of hypoadiponectinemia with impaired vasoreactivity.
|
12860835 |
2003 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes.
|
12802337 |
2003 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Among human adiponectin mutations, G84R and G90S mutants, which are associated with diabetes and hypoadiponectinemia, did not form HMW multimers.
|
12878598 |
2003 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The adiponectin gene is located on chromosome 3q27, where a diabetes susceptibility locus has been mapped.
|
15047634 |
2004 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes.
|
15123570 |
2004 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
There were no differences among the genotypes of the adiponectin gene regarding age, duration of diabetes, body mass index (BMI), hemoglobin A(1c) (HbA(1c)), serum lipids, serum creatinine, and plasma adiponectin levels.
|
15334388 |
2004 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
2) In contrast to previous studies, the presence of diabetes does not influence adiponectin serum levels after correction for BMI.
|
15239024 |
2004 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The complex aetiology of Type 2 diabetes, which probably involves a medley of molecular mechanisms, requires dissection out of diabetes-associated subphenotypes, such as the non-obese with increased liver fat or the obese with low plasma adiponectin.
|
15114471 |
2004 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians.
|
15616040 |
2005 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
These results facilitate the understanding of molecular mechanisms of adiponectin actions and obesity-linked diseases such as diabetes and atherosclerosis and propose the molecular targets for anti-diabetic and anti-atherogenic drugs.
|
15725703 |
2005 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
In offspring of diabetic parents, a population at high risk of diabetes and atherosclerotic disease, there is no relationship between total or %HMW adiponectin and endothelium-dependent vasodilation.
|
16091909 |
2005 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sequence variants in the adiponectin gene appear to be associated with diabetes and diabetes-related phenotypes.
|
16028335 |
2005 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The adiponectin gene is known to modulate adiponectin concentrations and diabetes mellitus development.
|
16210704 |
2005 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The present prospective investigation provides further evidence for a protective role of adiponectin gene variation in the risk of ischemic stroke that was independent of the presence of diabetes.
|
16990411 |
2006 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Cumulative rather than synergistic effects of PPARG Pro12Ala and APM1 SNPs on diabetes risk are suggested.
|
16567542 |
2006 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian population.
|
16933180 |
2006 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
AdipoR1 and adiponectin expression was associated in lean (r=0.943, P<0.005) and obese non-diabetic patients (r=0.74, P<0.01), whereas a positive correlation between adipoR2 and adiponectin expression was only found in the presence of diabetes (r=0.883, P<0.002).
|
16756736 |
2006 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes.
|
17052201 |
2006 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
In a subset of hyperglycemic L1 mice, we observed decreased mRNA expression of AdipoR2 in liver and muscle, as well as decreased peroxisome proliferator-activated receptor (PPAR)alpha target gene expression in liver, raising the possibility that deterioration of adiponectin/AdipoR2 signaling via PPARalpha activation contributes to the progression from compensated insulin resistance to diabetes.
|
17475934 |
2007 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin (Adipo), an adipocyte hormone involved in the regulation of glucose and lipid metabolism, has already been identified as a potential therapeutic target for the treatment of diabetes.
|
17868184 |
2007 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin has been associated with low diabetes risk.
|
17416799 |
2007 |