|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, an insulin-sensitizing hormone, and resistin, known to promote insulin resistance, constitute a potential link between obesity and type 2 diabetes.
|
26740596 |
2016 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the region on chromosome 11 has been associated with obesity and diabetes-related traits in adult populations, this is the first observation of linkage in this region for adiponectin levels.
|
16894363 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of altered levels of insulin, leptin and adiponectin in contributing to the observed increased risk of colon cancer associated with obesity remains to be determined.
|
22193626 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated to a low-grade inflammation that alters the expression of adiponectin, leptin, IL-6, Monocyte Chemotactic Protein 1 (MCP1), TRAIL, LIGHT/TNFSF14, OPG, and TNFα.
|
31130918 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity.
|
12750819 |
2003 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin is an adipose tissue specific protein that is decreased in subjects with obesity and type 2 diabetes.
|
18465144 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because the activation of cells involved in innate and adaptive immunity contributes to the pathogenesis of diseases such as atherosclerosis and obesity, this study investigated the role of adiponectin in human macrophage polarization and T cell differentiation.
|
22948153 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We evaluated 20 candidate variants in 4 genes previously shown to alter serum leptin and adiponectin levels for associations with obesity (BMI>30 kg/m2) and CRC risk.
|
30379922 |
2018 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that these common ACDC polymorphisms do not play a major role in susceptibility to obesity or type 2 diabetes in this population.
|
15616040 |
2005 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It is likely that the G allele of the ADIPOQ G276T polymorphism is a susceptibility allele for CVD in Japanese type 2 diabetic patients, especially when they accompany obesity.
|
22138143 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children.
|
15853826 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin is an important adipokine whose levels are decreased in obesity despite increases in adipocyte mass.
|
22594400 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
During the expansion of adipose tissue mass in obesity there is a major inflammatory response in the tissue with increased expression and release of inflammation-related adipokines, including IL-6, leptin, monocyte chemoattractant protein-1 and TNF-alpha, together with decreased adiponectin production.
|
18397542 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Iron content appears to be increased in the SCAT and VAT of obese patients, and negatively correlated with adiponectin expression, which could be contributing to insulin resistance and the metabolic complications of obesity.
|
26677772 |
2016 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, quercetin, vitamin D, and anti-obesity drugs have also been studied and seem to have a useful role in the treatment of obesity and metabolic syndrome in PCOS.
|
29344438 |
2017 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to use a family-based analysis to identify the genetic variants of the adiponectin (ADIPOQ) gene that are associated with obesity, insulin resistance, dyslipidemia and hypertension, among Arabs.
|
23845780 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interestingly, leptin and adiponectin expression in adipose tissue at weaning and at the time before the onset of obesity could be defined as early biomarkers of metabolic disturbance, predisposing towards adult obesity under the appropriate environment.
|
29329236 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
All anthropometric, clinical and metabolic factors as well as inflammatory and CVD risk biomarkers were higher in the obese than in the normal-BMI group, except adiponectin and HDL-c that were lower, and glucose, LDL-c, and metalloproteinase-9 that did not show difference.
|
24289790 |
2013 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our study on Tunisian patients shows impaired regulation of circulating and mRNA adiponectin levels dependent of metabolic disorders in obesity and Type 2 diabetes.
|
20651470 |
2011 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity increases the expression of leptin and other cytokines, as well as some macrophage and inflammatory markers, and decreases adiponectin expression in adipose tissue.A number of cytokines, e.g. tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1), and some pro-inflammatory interleukins, leuckocyte antigens, chemochines, surface adhesion molecules and metalloproteases are up-regulated whereas other factors are down-regulated.
|
17922949 |
2007 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, patients with obesity showed significantly lower serum adiponectin and higher serum leptin levels, but did not show differences in other adipokines.
|
29299904 |
2018 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related phenotype candidate genes include the gene encoding adiponectin (AdipoQ).
|
17992633 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Evaluation of the compound in vivo confirmed the reduced adiponectin response in animal models of obesity and diabetes while revealing strong beneficial effects on glucose, triglycerides, cholesterol, body weight, and other metabolic parameters.
|
19116277 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Only FTO rs9939609 A>T polymorphism was associated with obesity and no association was observed with ADIPOQ rs2441666 G>T and ACE rs4340288 DIP.
|
30416093 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Among the analyzed polymorphisms, only -11377C>G ADIPOQ single nucleotide polymorphism was associated with obesity during the prepubertal period.
|
26192702 |
2016 |