Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human adipocyte-specific apM-1 gene encodes a secretory protein of the adipose tissue and seems to play a role in the pathogenesis of obesity.
|
9765595 |
1998 |
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
|
10092513 |
1999 |
Obesity
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
|
10092513 |
1999 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adiponectin is secreted only from adipose tissue.
|
10092513 |
1999 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human adipocyte-specific apM-1 gene encodes a secretory protein of the adipose tissue that has been suggested to play a role in the pathogenesis of obesity.
|
10403784 |
1999 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Prospective longitudinal studies revealed that the plasma levels of adiponectin declined at an early phase of obesity and remained decreased after the development of type 2 diabetes.
|
11334417 |
2001 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.
|
11549668 |
2001 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The recently described mutations within the human adipocyte-specific apM-1 gene might play a role in the pathogenesis of obesity, type 2 diabetes and related metabolic disorders.
|
11571669 |
2001 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This regulation could contribute to the decreased apM1/ApN levels in insulin-resistant patients with obesity and the Metabolic Syndrome.
|
11700024 |
2001 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This suggests that in individuals without familial predisposition for type 2 diabetes, the adiponectin polymorphism may mildly increase the obesity risk (and secondarily insulin resistance).
|
11756320 |
2002 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude that variability at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome, but given the nature of the two SNPs, the risk haplotype is most probably a marker in linkage disequilibrium with an as yet unidentified polymorphism that affects plasma adiponectin levels and insulin sensitivity.
|
12086965 |
2002 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin (ACRP30), an adipocyte-secreted protein encoded by the APM1 gene, is known to modulate insulin sensitivity and glucose homeostasis, those effects protecting obese mice from diabetes.
|
12354786 |
2002 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Resistin and adiponectin expression was significantly lower in VAT of genetically obese in comparison with lean rats; no differences were observed when subcutaneous adipose tissues of the same animals were compared.
|
12429872 |
2002 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Despite adjustment for obesity-associated variables, plasma levels of adiponectin were significantly correlated to adiponectin gene expression (partial r = 0.38, P < 0.05).
|
12663465 |
2003 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity.
|
12750819 |
2003 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes.
|
12802337 |
2003 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To better understand the regulation of adiponectin expression, we measured plasma adiponectin and adipose tissue adiponectin mRNA levels in nondiabetic subjects with varying degrees of obesity and insulin resistance.
|
12829646 |
2003 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin-KO mice showed obesity, hyperglycemia, and hypertension compared with WT mice after 4 weeks on an atherogenic diet.
|
12860835 |
2003 |
Obesity
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.
|
14617771 |
2003 |
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.
|
14617771 |
2003 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding.
|
14671185 |
2003 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data suggest a potential interaction between the adiponectin genotype and PPAR gamma genotype or obesity, but these analyses should be considered exploratory and require further investigation in larger studies.
|
14693717 |
2004 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance.
|
14764792 |
2004 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We measured serum concentration and sc adipose tissue secretion rate of adiponectin in 77 obese and 23 nonobese women with a varying degree of insulin sensitivity.
|
15001639 |
2004 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The plasma concentration of the adipocyte-derived peptide adiponectin is decreased in patients with obesity and type 2 diabetes.
|
15047634 |
2004 |