Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Thus, the aim of this research will be to evaluate the effect of supplementation with total anthocyanin-base standardized cornelian cherry fruit extract on liver function (Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), cytokeratin-18 fragment M30 (CK-18 M30), as well as steatosis and fibrosis of liver), tumor necrosis factor α (TNF-α), malondealdehyde (MDA), and adiponectin in patients with NAFLD. 31324181 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE This review attempts to evaluate the usefulness of serum adiponectin, serum leptin, serum ferritin, serum transforming growth factor-β1 (TGF-β1), and serum platelet derived growth factor-BB (PDGF-BB) as non-invasive markers in the diagnosis of liver fibrosis/cirrhosis. 30231008 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Adiponectin inhibits hepatic stellate cell (HSC) activation and subsequent development of liver fibrosis via multiple mechanisms. 30293572 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 AlteredExpression disease BEFREE Adiponectin has antifibrogenic activity protecting from liver fibrosis, which is mainly driven by activated hepatic stellate cells (HSC). 27083512 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Serum from patients with liver fibrosis was examined for adiponectin and tissue inhibitor of metalloproteinase-1 (TIMP-1) protein. 25575598 2015
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Adiponectin, an adipocyte-derived insulin-sensitizing hormone, might play a protective role against hepatic fibrosis. 21539538 2011
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. 21846328 2011
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE We therefore conclude that the protective effects of adiponectin against liver fibrosis require AMPK activation, and may occur through inhibition of the Jak-Stat signal transduction pathway. 20564215 2010
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Adiponectin SNPs were found to be associated with the progression of liver fibrosis and insulin resistance, suggesting that adiponectin SNPs might play roles in the occurrence and progression of NAFLD. 19484180 2009
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Adiponectin limits the development of liver fibrosis and activates adenosine monophosphate-activated protein kinase (AMPK). 18098312 2008
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.100 Biomarker disease BEFREE Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B. 17462782 2007