NRXN1, neurexin 1, 9378

N. diseases: 139; N. variants: 41
Disease: Postoperative cognitive dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4721773
Disease: Postoperative cognitive dysfunction
Postoperative cognitive dysfunction 		0.010 Biomarker phenotype BEFREE The overexpression of NL1 can upregulate the expression levels of PV, Nrx1β and PSD95 in mice with POCD, enhance the interaction between NL1 and Nrx1β and further increase the excitability of PV interneurons, thus restoring the hippocampus-dependent memorial and cognitive impairment in POCD. 30936983 2019