|
Vasculitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recognition of α-mannan by D2 played an important role in the onset of vasculitis in the studied murine model.
|
30924376 |
2020 |
|
Infection by Cryptococcus neoformans
|
0.020 |
Biomarker
|
disease |
BEFREE |
Dectin-2-mediated signaling triggered by the cell wall polysaccharides of Cryptococcus neoformans.
|
31544981 |
2019 |
|
Vasculitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, the induction of AAV-IL-10 prevented the expression of TNF-α and IL-6, but not GM-CSF and Dectin-2 at the early phase of CAWS-induced vasculitis.
|
29765083 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.
|
27872290 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.
|
27872290 |
2016 |
|
Infection by Cryptococcus neoformans
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the association between Dectin-2 genetic polymorphisms and cryptococcosis among a series of human immunodeficiency virus (HIV)-uninfected Chinese patients.
|
26129889 |
2015 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Putative biomarkers such as cell cycle related genes (Cdc37), cancer cell adhesion (Glycam 1, integrin alpha8, integrin alphaX and Clec4n), signal transduction (Tlr2, IL-33, and Ccbp2), migration (Ccr1, Ccl6, and diaphorase 1 (Cyb5r3) and cancer development (epiregulin) can be useful for diagnosis and as prognosis markers and some of the target molecules can be applied for prevention of cancer.
|
19082487 |
2009 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Putative biomarkers such as cell cycle related genes (Cdc37), cancer cell adhesion (Glycam 1, integrin alpha8, integrin alphaX and Clec4n), signal transduction (Tlr2, IL-33, and Ccbp2), migration (Ccr1, Ccl6, and diaphorase 1 (Cyb5r3) and cancer development (epiregulin) can be useful for diagnosis and as prognosis markers and some of the target molecules can be applied for prevention of cancer.
|
19082487 |
2009 |
|
Mucocutaneous Lymph Node Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a murine model of systemic Kawasaki disease (KD)-like vasculitis induced by Candida albicans cell-wall-derived mannan · β-glucan · protein complexes, the objective was to elucidate the relationships of β-glucan receptor dectin-1 (D1) and α-mannan receptor dectin-2 (D2) to the onset of that vasculitis.
|
30924376 |
2020 |
|
Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We therefore evaluated whether hematopoietic deletion of Dectin-2 or CARD9 reduces inflammation and atherosclerosis development.
|
30867470 |
2019 |
|
Atherosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We therefore evaluated whether hematopoietic deletion of Dectin-2 or CARD9 reduces inflammation and atherosclerosis development.
|
30867470 |
2019 |
|
Vascular inflammations
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings demonstrate that Dectin-2-mediated induction of CCL2 production by macrophages resident in the aortic root and coronary arteries initiates vascular inflammation in a model of Kawasaki disease, suggesting an important role for the innate immune system in initiating vasculitis.
|
31169521 |
2019 |
|
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we used novel multi-CLR knockout (KO) mice to decipher the individual, collaborative and collective roles of Dectin-1, Dectin-2 and Mincle during systemic C. albicans infection.
|
31242262 |
2019 |
|
Neutrophil extracellular trap formation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dectin-2-Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation.
|
30393083 |
2019 |
|
Atherosclerotic lesion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deletion of hematopoietic Dectin-2 did not affect atherosclerotic lesion area, immune cell composition, ex vivo cytokine secretion by peritoneal cells or bone marrow derived macrophages.
|
30867470 |
2019 |
|
Cystic Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Dectin-1 and Dectin-2 cleavage by NE and/or A. fumigatus-derived proteases results in an aberrant antifungal immune response that likely contributes to disease pathology in patients with CF.-Griffiths, J. S., Thompson, A., Stott, M., Benny, A., Lewis, N. A., Taylor, P. R., Forton, J., Herrick, S., Orr, S. J., McGreal, E. P. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases.
|
29401615 |
2018 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dectin-2 is a C-type lectin involved in the recognition of several pathogens such as Aspergillus fumigatus, Candida albicans, Schistosoma mansonii, and Mycobacterium tuberculosis that triggers Th17 immune responses.
|
30443026 |
2018 |
|
Pneumocystis jiroveci pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble Dectin-2 carbohydrate-recognition domain fusion protein showed binding to intact Pneumocystis carinii (Pc) and to native Pneumocystis major surface glycoprotein/glycoprotein A (Msg/gpA).
|
28886250 |
2018 |
|
Malassezia folliculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpression of NLRP3, NLRC4 and AIM2 inflammasomes and their priming-associated molecules (TLR2, TLR4, Dectin-1, Dectin-2 and NFκB) in Malassezia folliculitis.
|
28976036 |
2018 |
|
Cholesteatoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The levels of CD206 (cluster of differentiation 206), DEC-205 (Dendritic and epithelial cell-205), MGL (monoacylglycerol lipase), CLEC5A (C-type lectin domain family 5 member A), Dectin-2 (dendrite cell-associated C-type lectin-2), BDCA2 (Blood dendritic cell antigen 2), Mincle, DCIR (dendritic cell immunoreceptor), Dectin-1, MICL (Myeloid inhibitory C type-like lectin), and CLEC12B (C-type lectin domain family 12, member B) mRNAs were significantly higher in cholesteatoma than in control skin samples (p < 0.05).
|
28440726 |
2017 |
|
Myocardial rupture
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 differentiation.
|
28193608 |
2017 |
|
Mycoses
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In this report, we demonstrate that in mouse LAP is linked to dendritic cell-associated lectin 2 (Dectin-2), a C-type lectin specific to fungal α-mannan polysaccharide.
|
29118762 |
2017 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased expression of α-smooth muscle actin and collagen I/III was observed, whereas the levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 were decreased in the hearts of Dectin-2 knockout mice after MI.
|
28193608 |
2017 |
|
Infectious Lung Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Results of pulmonary infection with H. capsulatum showed that CD103+ DCs are one of the major producers of IL-1β and Dectin-2 and Dectin-1 double deficiency abolishes their IL-1β response to the fungus.
|
28671985 |
2017 |
|
Dermatophytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we uncovered the C-type lectin receptors, Dectin-1 and Dectin-2, as key elements in the immune response to T. rubrum infection in a model of deep dermatophytosis.
|
27189427 |
2016 |