GRAP2, GRB2 related adaptor protein 2, 9402

N. diseases: 538; N. variants: 9
Disease: Cholangiocarcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.040 GeneticVariation disease BEFREE WWOX suppresses cell growth and induces cell apoptosis via inhibition of P38 nuclear translocation in cholangiocarcinoma. 25502636 2014
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.040 Biomarker disease BEFREE Taken together, these data provide a potential mechanism to explain how p38 promotes human cholangiocarcinoma cell proliferation and invasion. 23024367 2012
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.040 Biomarker disease BEFREE We conclude that modulation of IL-6 mediated survival signaling pathways involving the p38 MAPK or downstream targets such as Mcl-1 may prove useful therapeutic strategies for human cholangiocarcinoma. 16469407 2006
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.040 AlteredExpression disease BEFREE In vitro analysis revealed that WISP1v stimulated the invasive phenotype of cholangiocarcinoma cells with activation of both p38 and p42/p44 mitogen-activated protein kinases (MAPKs). 12717393 2003