|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Orthotopically implanted TCC-Pan2 cells caused tumor formation and PD with high frequency in mice.
|
30747829 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We established 3 HMPM cell lines (TCC-MESO-1, TCC-MESO-2 and TCC-MESO-3) from Japanese patients; the first 2 from the primary and metastatic tumors of a patient with the epithelioid type of HMPM, and the third from a patient with biphasic characteristics of the tumor (epithelioid and sarcomatous phenotypes).
|
19876922 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that some DNA repair gene polymorphisms may preoperatively be valuable as prognostic factors for UUT-TCC beyond tumor stage and grade, helping to provide optimal treatment strategies for individual patients.
|
18320070 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among the CD44 variant isoforms on 55 TCC tissue specimens examined, the expression of CD44v5 was inversely related to tumor grade, stage and recurrence, while the expression of CD44v10 was positively related to tumor recurrence.
|
14981907 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results confirm previous studies that 1.) both c-erbB-2 and VEGF are over-expressed in these tumors MLI = 90.1 and 45.7 respectively, 2.) that VEGF is an early and sensitive indicator of TCC, and 3.) that BCG has a salutary effect on papillary TCC, 66% vs. 89% recurrence rate, P = .04.Our findings show that 1.)
|
12474525 |
2002 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In one tumor mutation at codon 922 TCC(Ser)-->TTC(Phe) in exon 16 was found.
|
11692159 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The analysis of one tumour having areas of both SCC and transitional cell carcinoma strongly suggests that SCC can develop from TCC through the acquisition of additional genetic alterations.
|
10547580 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In normal urothelium, its expression was restricted to the basal cell layers, whereas in the dysplastic lesions of TCC-UUT it was detected with the same intensity and distribution as in the tumor itself.
|
10570439 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LOH analysis suggests that multiple tumor suppressor genes play a role in the development of human TCC.
|
9764827 |
1998 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In sequence analysis, an unusual mutation of alternate three-base deletions at nucleotides 1953-1957 (AAA GAT ACC to AAG TCC), resulting in one amino acid deletion (Asp at 619) and one conservative amino acid substitution (Thr to Ser at 620), was identified in tumor DNA but not in leukocyte DNA of no.21.
|
7673402 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumour cell line (CAT), derived from a patient with well-differentiated (G3pTa) TCC, has been in culture for 24 months and subcultured more than 100 times.
|
1828972 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that trisomy 7 could be a primary change in TCC, and a review of the literature indicates that when it is present as the sole karyotypic abnormality is may be associated with a non-invasive behavior of the tumor.
|
2253193 |
1990 |