|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Circulating tumor markers (β-subunit of human chorionic gonadotropin (β-HCG), alpha-Fetoprotein (AFP), and Lactate Dehydrogenase (LDH)) are frequently used for monitoring disease recurrence in TGCT patients, though they lack diagnostic sensitivity and specificity.
|
30321995 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Of these 19 patients, 17 did not have elevated CSF HCG-β levels or express HCG-β in the tumor tissue.
|
28819802 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical staining of tumor sections revealed overexpression of the LH/hCG receptor.
|
21324830 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We describe a case with aberrant adrenal LH/hCG receptors in a large adrenal tumor as a possible explanation for cortisol hypersecretion and tumor growth in Cushing s syndrome during pregnancy.
|
19636197 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study shows that glycodelin A stimulates the secretion of hCG protein in Jeg3 trophoblast tumour cells in a time- and dose-dependent manner.
|
12820356 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In these patients malignant non-seminomatous GCT may be diagnosed clinically due to the increased serum or cerebrospinal fluid levels of the tumor markers AFP and/or beta-HCG.
|
10811491 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Evaluating the 20 patients with beta-HCG-secreting tumors, 100% of PCR-positive patients had elevated serum beta-HCG at the time of apheresis compared to 46.2% of PCR-negative patients (P = 0.04).
|
9516957 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mRNA expression of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors was analysed by the RT-nested PCR method in five normal ovarian tissues, 62 ovarian tumours (5 benign, 7 borderline and 43 malignant epithelial tumours, 3 sex cord-stromal tumours and 4 germ cell tumours) and in 2 ovarian cancer cell lines.
|
9337696 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Northern blotting demonstrated that endometrial carcinomas contain a greater abundance of multiple LH/hCG receptor transcripts, which increased with increasing tumor grade.
|
7962347 |
1994 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Since predicting the biologic behavior of placental site trophoblastic tumor is very difficult, making a correct diagnosis on endometrial curettings, hysterectomy, and monitoring serum HCG level is essential in patients with this tumor.
|
8396853 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A high degree of correlation was observed between the various techniques revealing CgA and/or CgB gene expression at different levels; minor discrepancies might be related to tumor heterogeneity or to technical factors.
|
2305832 |
1990 |
|
Down Syndrome
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The analyses stress the importance of using a software which has the possibility to separate the level of a biochemical risk by correlating PAPP-A and free beta HCG and, by adding the NT marker, calculate the level of a final risk of Down syndrome.
|
30581343 |
2018 |
|
Down Syndrome
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We present the case of a pregnant woman with low free beta-HCG in maternal serum Down syndrome screening that led to prenatal diagnosis of a fetus with 46,XY,der(4)t(4;11)(p14; q25).
|
16231301 |
2005 |
|
Down Syndrome
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We concluded that in trisomy 21 the high tissue HCG concentration and expression of LH/HCG receptor in the trophoblast may reflect the relative immaturity of the trophoblastic tissue whereas in trisomy 18, the very low concentration of endogenous HCG, associated with an over-expression of LH/HCG receptor in the trophoblast, is probably secondary to the poor differentiation of the cytotrophoblast.
|
10611254 |
2000 |
|
Down Syndrome
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The increase in hCG promoter activity in DS-derived fibroblasts suggests a possible role for a transcriptional factor located on the human chromosome 21 by either directly or indirectly interacting with the beta5-promoter.
|
10085509 |
1999 |
|
Down Syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
Significant correlations were found for AFP and UE3 in the controls and for intHCG and F beta HCG in both the control and the Down's syndrome pregnancies.
|
8284287 |
1993 |
|
Down Syndrome
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The addition of two new markers in maternal serum, estriol and HCG, to those already known, namely the level of maternal serum alfa-fetoprotein and maternal age, considerably improves the expected results of a screening strategy for Down syndrome.
|
1689225 |
1990 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In ovarian cancer CGB expression positively correlated with TFAP2A transcripts level and expression of TFAP2A transcription factor was significantly higher in cancer than in control tissues.
|
31362717 |
2019 |
|
Choriocarcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The tumor cells showed focal positivity for CDX2 (adenocarcinoma component), HCG (choriocarcinoma) and CD138 (plasmacytoid carcinoma component) and were negative for HER-2, α-fetoprotein, VEGF, maspin and markers of epithelial-mesenchymal transition.
|
31417929 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In ovarian cancer CGB expression positively correlated with TFAP2A transcripts level and expression of TFAP2A transcription factor was significantly higher in cancer than in control tissues.
|
31362717 |
2019 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The patient's thyroid function normalised with treatment of the cancer as the beta HCG levels declined.
|
29884717 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The patient's thyroid function normalised with treatment of the cancer as the beta HCG levels declined.
|
29884717 |
2018 |
|
Complete Trisomy 21 Syndrome
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The analyses stress the importance of using a software which has the possibility to separate the level of a biochemical risk by correlating PAPP-A and free beta HCG and, by adding the NT marker, calculate the level of a final risk of Down syndrome.
|
30581343 |
2018 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The transcription of these genes, but not other CGB genes, correlates with a functionally expressed protein and propensity for cancer growth.
|
24778026 |
2014 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The transcription of these genes, but not other CGB genes, correlates with a functionally expressed protein and propensity for cancer growth.
|
24778026 |
2014 |