MIRROR MOVEMENTS 4
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
MIRROR MOVEMENTS 4
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in the netrin-1 gene cause congenital mirror movements.
|
28945198 |
2017 |
Subarachnoid Hemorrhage
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
The expression of endogenous NTN-1 and its receptor Deleted in Colorectal Cancer were increased after SAH.
|
28526701 |
2017 |
Subarachnoid Hemorrhage
|
0.350 |
Biomarker
|
disease |
BEFREE |
The endovascular perforation SAH model was constructed using male C57BL/6J mice, and recombinant NTN-1 was administrated intravenously.
|
30614619 |
2019 |
Subarachnoid Hemorrhage
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that endogenous NTN-1 and its receptor UNC5B level were increased after SAH.
|
29162556 |
2018 |
Subarachnoid Hemorrhage
|
0.350 |
Biomarker
|
disease |
CTD_human |
Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats.
|
29162556 |
2018 |
Subarachnoid Hemorrhage
|
0.350 |
Biomarker
|
disease |
BEFREE |
This study was designed to discern the utility of serum netrin-1 as a biomarker for assessing the severity and prognosis of patients with aneurysmal SAH.
|
31047878 |
2019 |
Subarachnoid Hemorrhage
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Our results revealed that endogenous NTN-1 level was increased after SAH.
|
28347836 |
2017 |
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
Rheumatoid Arthritis
|
0.110 |
Biomarker
|
disease |
BEFREE |
Treating the SF-cells with recombinant Netrin-1 resulted in inhibition of migration of RA- and OA-SFs whereas control cells were not affected.
|
19822088 |
2009 |
Cleft upper lip
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate.
|
25775280 |
2015 |
Cleft upper lip
|
0.110 |
Biomarker
|
disease |
BEFREE |
NTN1 gene was risk to non-syndromic cleft lip only among Han Chinese population.
|
30506619 |
2019 |
Cleft upper lip
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
|
22863734 |
2012 |
Cleft upper lip
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.
|
20436469 |
2010 |
Cleft upper lip
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate.
|
28054174 |
2017 |
Mirror movements disorder
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
Mirror movements disorder
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the netrin-1 gene cause congenital mirror movements.
|
28945198 |
2017 |
Cerebral Palsy
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Cleft Palate
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate.
|
28054174 |
2017 |
Cleft Palate
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate.
|
25775280 |
2015 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The majority of CRCs harbor defects in Netrin-1 receptors, emphasizing the importance of this growth regulatory pathway in cancer.
|
18054557 |
2007 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, our own studies have shown that Netrin-1/Deleted in Colorectal Cancer (DCC) signaling triggers exocytosis through the SNARE Syntaxin-1 (STX1).
|
29912942 |
2018 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In ADSC-treated rats, the expression of netrin-1 and DCC significantly increased in the peri-infarct cortex at days 7 and 14.
|
29017609 |
2017 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DCC gene expression is lost or markedly reduced in the majority of advanced colorectal cancers and, by functioning as a dependence receptor, DCC has been shown to induce apoptosis unless engaged by its ligand, netrin-1 (ref.2).
|
22158121 |
2011 |
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, netrin-1 up-regulation, which is associated with tumor formation in mice, is observed in mouse colonic crypts in response to NF-kappaB activation but also in a mouse model of inflammation-induced colorectal cancer.
|
18692059 |
2008 |