|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunostaining was performed for Netrin-1 (deleted in colorectal carcinoma [DCC], UNC5A) and GDNF receptors (rearranged during transfection [Ret], glycosylphosphatidylinositol-linked cell surface receptors [GFRα1, GFRα2, GFRα3]).
|
30811036 |
2019 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phenotypic analogy to mice with homozygous inactivation of Ntn1 encoding the secreted axonal guidance protein netrin1, or Dcc encoding its receptor Deleted in Colorectal Cancer led us to perform sequence analysis of NTN1 and DCC in all the patients.No pathogenic mutations were found.
|
17690130 |
2007 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic alterations in the netrin-1 receptors have been found to be related with the
|
29801399 |
2018 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Netrin-1 receptors might act as a tumor suppressor in colorectal cancers, and thus methylation might present a malignant potential in colorectal cancer.
|
19242752 |
2009 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Firstly identified as a tumor suppressor gene in human colorectal carcinomas, the main function for DCC has been described in the nervous system as part of a receptor complex for netrin-1.
|
16762451 |
2006 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers.
|
15956977 |
2005 |
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, GO and GO-COOH up-regulated expression of Netrin-1 and its receptor, deleted in colorectal cancer by immunofluorescence assays and western blots assay.
|
29377591 |
2018 |
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of endogenous NTN-1 and its receptor Deleted in Colorectal Cancer were increased after SAH.
|
28526701 |
2017 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, we demonstrate that this inflammation-driven netrin-1 up-regulation is causal for colorectal cancer development as interference with netrin-1 autocrine loop in a mouse model for ulcerative colitis-associated colorectal cancer, while showing no effect on inflammation, inhibits colorectal cancer progression.
|
19721007 |
2009 |
|
Mild Mental Retardation
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Agenesis of corpus callosum
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hypogonadotropic hypogonadism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Fused cervical vertebrae
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Oral cleft
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate.
|
28054174 |
2017 |
|
Specific learning disability
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Dysgenesis of the hippocampus
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Additionally, GO and GO-COOH up-regulated expression of Netrin-1 and its receptor, deleted in colorectal cancer by immunofluorescence assays and western blots assay.
|
29377591 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
Biomarker
|
disease |
BEFREE |
Moreover, we demonstrate that this inflammation-driven netrin-1 up-regulation is causal for colorectal cancer development as interference with netrin-1 autocrine loop in a mouse model for ulcerative colitis-associated colorectal cancer, while showing no effect on inflammation, inhibits colorectal cancer progression.
|
19721007 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
Netrin-1 receptors might act as a tumor suppressor in colorectal cancers, and thus methylation might present a malignant potential in colorectal cancer.
|
19242752 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
Biomarker
|
disease |
BEFREE |
Phenotypic analogy to mice with homozygous inactivation of Ntn1 encoding the secreted axonal guidance protein netrin1, or Dcc encoding its receptor Deleted in Colorectal Cancer led us to perform sequence analysis of NTN1 and DCC in all the patients.No pathogenic mutations were found.
|
17690130 |
2007 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
Biomarker
|
disease |
BEFREE |
Indeed, our own studies have shown that Netrin-1/Deleted in Colorectal Cancer (DCC) signaling triggers exocytosis through the SNARE Syntaxin-1 (STX1).
|
29912942 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In ADSC-treated rats, the expression of netrin-1 and DCC significantly increased in the peri-infarct cortex at days 7 and 14.
|
29017609 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
Biomarker
|
disease |
BEFREE |
Netrin-1 receptors are aberrantly methylated
|
29801399 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Moreover, netrin-1 up-regulation, which is associated with tumor formation in mice, is observed in mouse colonic crypts in response to NF-kappaB activation but also in a mouse model of inflammation-induced colorectal cancer.
|
18692059 |
2008 |
|
Malignant neoplasm of colon and/or rectum
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The expression of endogenous NTN-1 and its receptor Deleted in Colorectal Cancer were increased after SAH.
|
28526701 |
2017 |