|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Netrin-1 concentrations were significantly down regulated in both serum and cerebrospinal fluid (CSF) of these AD rats, effects which were strongly correlated with cognitive deficits.
|
31191297 |
2019 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
UNC5C, which is a transmembrane receptor for netrin-1 to trigger the apoptosis, has been confirmed as a new risk factor for Alzheimer's disease (AD) recently.
|
26660111 |
2016 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Molecular characterization of Netrin-1 and APP receptor binding: New leads to block the progression of senile plaques in Alzheimer's disease.
|
28501620 |
2017 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Finally, to support further study of netrin-1's potential as a therapeutic for Alzheimer's disease, pilot gene therapy studies were performed and a netrin mimetic peptide synthesized and tested that, like netrin, can increase sAβPPα and decrease Aβ1-42in vitro.
|
27060954 |
2016 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Therefore, based on the data reported here, netrin-1 may be a promising biologic therapeutic that addresses the memory and neuronal loss associated with AD.
|
30066400 |
2019 |
|
Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Present findings provide support for the hypothesis that dysregulation of expression of NTN1 in SMCs and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques.
|
24122613 |
2013 |
|
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Concerning the cardiovascular realm, netrin-1 promotes angiogenesis and accelerates atherosclerosis, protects the heart against ischemia-reperfusion injury, and reduces the infarct size.
|
24262644 |
2014 |
|
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Thus, netrin-1 promoted atherosclerosis by retaining macrophages in the artery wall.
|
22231519 |
2012 |
|
Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
However, the mechanisms governing netrin-1 expression in atherosclerosis are not well understood.
|
23599441 |
2013 |
|
Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Netrin-1 plasma levels are lower in patients with subclinical atherosclerosis and in patients with arterial wall inflammation.
|
31801376 |
2020 |
|
Atherosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Thus, netrin-1 promoted atherosclerosis by retaining macrophages in the artery wall.
|
22231519 |
2012 |
|
Atherosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
However, the mechanisms governing netrin-1 expression in atherosclerosis are not well understood.
|
23599441 |
2013 |
|
Atherosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Netrin-1 plasma levels are lower in patients with subclinical atherosclerosis and in patients with arterial wall inflammation.
|
31801376 |
2020 |
|
Atherosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Present findings provide support for the hypothesis that dysregulation of expression of NTN1 in SMCs and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques.
|
24122613 |
2013 |
|
Atherosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Concerning the cardiovascular realm, netrin-1 promotes angiogenesis and accelerates atherosclerosis, protects the heart against ischemia-reperfusion injury, and reduces the infarct size.
|
24262644 |
2014 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
Since regenerative, angiogenic and anti-inflammatory properties of Netrin-1 have been reported in multiple tissues, we have investigated the potential role of Netrin-1 in the endocrine islet and its implication in mice with high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes.
|
27520508 |
2016 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we provide evidence in both vitreous humor of diabetic patients and in retina of a murine model of diabetes that netrin-1 is metabolized into a bioactive fragment corresponding to domains VI and V of the full-length molecule.
|
27400127 |
2016 |
|
Diabetes
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The relationship of the netrin-1 levels with diabetes parameters such as fructosamine, hemoglobin A1c (HbA1c) or duration of diabetes was investigated.
|
31219796 |
2019 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
We report a protective role for Netrin-1 against MI-induced ischemic injuries, reinstating its promising potential as a therapeutic target for CVDs and, more importantly, for patients with CVD with coexisting diabetes.
|
24827071 |
2014 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
Enhancement of netrin-1 function may be a useful therapeutic means for preventing vascular dysfunction in diabetes.
|
29059224 |
2017 |
|
Middle Cerebral Artery Occlusion
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We found that netrin-1 infusion improved neurological function, attenuated secondary impairment of BBB by up-regulating the levels of tight junction proteins and diminishing extravasation of albumin, with autophagy activation 14 days after MCAO.
|
29311781 |
2017 |
|
Middle Cerebral Artery Occlusion
|
0.050 |
Biomarker
|
disease |
BEFREE |
The effect of netrin-1 on brain tissues and endothelial cells was examined by immunohistochemistry and western blotting in a middle cerebral artery occlusion model and in human umbilical vein endothelial cells.
|
27558487 |
2017 |
|
Middle Cerebral Artery Occlusion
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Netrin-1 overexpression increased neurobehavioral test scores and reduced cerebral infarct volume following MCAO via inhibition of the Notch1 signaling pathway.
|
28084632 |
2017 |
|
Middle Cerebral Artery Occlusion
|
0.050 |
Biomarker
|
disease |
BEFREE |
In vivo studies showed that knockdown of netrin-1 increased astrocyte activation in the mouse brain after middle cerebral artery occlusion (p < 0.05).
|
30227858 |
2018 |
|
Middle Cerebral Artery Occlusion
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
In this study, we used Adeno-associated vectors carrying Netrin-1 gene (AAV-NT-1) to up-regulate the expression level of Netrin-1 in rats' brain after middle cerebral artery occlusion (MCAO).
|
29487502 |
2018 |