|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3.
|
31691080 |
2020 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we investigate the expression of two ABC transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), in human IPF lung tissue and two different bleomycin-induced mouse models of pulmonary fibrosis.
|
31419911 |
2020 |
|
Erythroplakia of mouth
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, we observed that the expression of podoplanin and ABCG2 within a single pre-neoplastic OE lesion significantly correlate with subsequently developing multiple and multifocal carcinomas, thus to some extent demonstrating the concept of field cancerization.
|
31300272 |
2020 |
|
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, BDL decreases the function and expression of brain BCRP in rats, leading to increased brain distribution of AZT, which in turn enhances AZT CNS toxicity, leading to mitochondrial dysfunction, neuronal damage, and ultimately cognitive dysfunction.
|
31142800 |
2020 |
|
Oropharyngeal disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, murine lungs expressed increased levels of P-gp and BCRP after oropharyngeal and subcutaneous bleomycin administration.
|
31419911 |
2020 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We report that P-gp and BCRP expression in IPF patient lungs was comparable to controls.
|
31419911 |
2020 |
|
Malignant neoplasm of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to evaluate how CYP3A4/5 and ABC transporter polymorphisms affected the mean steady-state dose-adjusted plasma trough concentrations (C<sub>0</sub>) of lenvatinib in a cohort of 40 Japanese patients with thyroid cancer.
|
30931962 |
2019 |
|
Cholelithiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A second ABC transporter, the hepatic phosphatidylcholine translocase ABCB4, increases the risk for gallstone disease, gallbladder cancer and chronic liver diseases in general, whereas the common PNPLA3 risk variant p.I148M decreases gallstone risk.
|
30608254 |
2019 |
|
Dermatitis, Atopic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of P-gp and BCRP was reduced in oxazolone-treated skin and the skin of patients with atopic dermatitis or psoriasis.
|
31512001 |
2019 |
|
Eczema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of P-gp and BCRP was reduced in oxazolone-treated skin and the skin of patients with atopic dermatitis or psoriasis.
|
31512001 |
2019 |
|
Kidney Calculi
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ABCG2 SNP rs2231142 and the gout comorbidities including nephrolithiasis and CKD were associated (<i>P</i> = 0.014 and <i>P</i> = 0.026).
|
31367212 |
2019 |
|
Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Based on our previous studies, we hypothesized that glutamate released during seizures activates cytosolic phospholipase A2 (cPLA2), resulting in P-gp and BCRP overexpression.
|
31661303 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Information about BCRP function in EVTs is limited, however placental exposure to bacterial/viral infection leads to BCRP downregulation in syncitiotrophoblasts.
|
31561453 |
2019 |
|
Iron deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, a larger amount of ABC transporter genes was induced or suppressed by iron deficiency under Cd exposure, indicating that this family may play important roles in Fe/Cd uptake and transport.
|
30665365 |
2019 |
|
Nephrolithiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ABCG2 SNP rs2231142 and the gout comorbidities including nephrolithiasis and CKD were associated (<i>P</i> = 0.014 and <i>P</i> = 0.026).
|
31367212 |
2019 |
|
Thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to evaluate how CYP3A4/5 and ABC transporter polymorphisms affected the mean steady-state dose-adjusted plasma trough concentrations (C<sub>0</sub>) of lenvatinib in a cohort of 40 Japanese patients with thyroid cancer.
|
30931962 |
2019 |
|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that gastrointestinal cancer cell lines expressing high levels of ABCG2 are enriched with CSCs and show low rates of 5-ALA staining, but 5-ALA staining rates can be improved by inhibition of ABCG2.
|
31083682 |
2019 |
|
Malaria, antepartum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, a decrease in placental Abca1 (ABCA1), Abcb1b (P-glycoprotein), Abcb9 and Abcg2 (BCRP) expression was observed in MiP mice.
|
31391498 |
2019 |
|
Biliary Tract Cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We then demonstrated that knockdown of GPX4, CAT, or GSR induced chemoresistance through elevation of ROS level and activation of Nrf2-ABCG2 pathway in BTC cell lines.
|
31590928 |
2019 |
|
MOHR-TRANEBJAERG SYNDROME
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study observed that in ovarian cancer cells, the expression of ABCG2 was significantly upregulated in response to cis-diamminedichloroplatinum (cisplatin/DDP) treatment, in addition the expression of NOS1 exhibited an increasing trend.
|
30675218 |
2019 |
|
Cholecystolithiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A second ABC transporter, the hepatic phosphatidylcholine translocase ABCB4, increases the risk for gallstone disease, gallbladder cancer and chronic liver diseases in general, whereas the common PNPLA3 risk variant p.I148M decreases gallstone risk.
|
30608254 |
2019 |
|
Traditional Serrated Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In these two cell lines, the HDAC inhibitors suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) significantly increased ABCB1 expression at the mRNA and protein levels, whereas they had no evident effect on ABCG2 protein expression.
|
31289473 |
2019 |
|
Drug Dependence
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Thus, prolonged exposure to commonly abused drugs, ethanol and cocaine, alters the expression of Abcb1/ABCB1 and Abcg2/ABCG2 mRNA and protein levels in brain areas that play a role in drug dependence.
|
29978425 |
2019 |
|
Chronic kidney disease stage 2
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Group CKD stage = 1 were significantly different from those in group CKD stage≥2 regarding genotypes of ABCG2 gene polymorphism, while they were not significantly different from those in group CKD stage≥3.
|
31367212 |
2019 |
|
Chronic kidney disease stage 3
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Group CKD stage = 1 were significantly different from those in group CKD stage≥2 regarding genotypes of ABCG2 gene polymorphism, while they were not significantly different from those in group CKD stage≥3.
|
31367212 |
2019 |