|
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1
|
0.600 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Glioblastoma Multiforme
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions.</b> In summary, RES529, the first dual TORC1/TORC2 dissociative inhibitor, lacking affinity for ABCB1/ABCG2 and having good brain penetration, was active in GBM preclinical/murine models giving credence to its use in clinical trial for patients with GBM treated in association with anti-angiogenetic compounds.
|
31640252 |
2019 |
|
Hyperuricemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
<i>Cichorium intybus</i> L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia.
|
28630638 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<sup>68</sup>Ga[Ga]-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells.
|
29454148 |
2018 |
|
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<sup>68</sup>Ga[Ga]-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells.
|
29454148 |
2018 |
|
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<sup>68</sup>Ga[Ga]-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells.
|
29454148 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
2) The protein presence of MDR1 and BCRP in MDR tumors was also significantly higher than those in the control group in vivo and in clinical specimens.
|
20437864 |
2010 |
|
Adrenoleukodystrophy
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
X-linked adrenoleukodystrophy (X-ALD) is a demyelinating disorder associated with impaired very-long-chain fatty-acid (VLCFA) beta-oxidation caused by mutations in the ABCD1 (ALD) gene that encodes a peroxisomal membrane ABC transporter.
|
12761339 |
2003 |
|
Acute monocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
AML sample BCRP mRNA levels were between those in parental 8226 and 35-fold mitoxantrone-resistant 8226/MR20 cells in all but one case, and BCRP mRNA had the wild-type sequence at codon 482 in all.
|
15208643 |
2004 |
|
Malignant Squamous Cell Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade.
|
18219291 |
2008 |
|
Adrenoleukodystrophy
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP).
|
20166112 |
2010 |
|
Cystic Fibrosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Cystic fibrosis (CF) is an inherited, life-threatening disease caused by mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), an ABC transporter-class protein and ion channel that transports ions across epithelial cell membranes.
|
21050065 |
2010 |
|
Age related macular degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Age-related macular degeneration (AMD) is a multifactorial disease for which an involvement of alterations in the retinal ABC transporter gene (ABCA4) is still debated.
|
22706241 |
2012 |
|
Adrenoleukodystrophy
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene that encodes the peroxisomal ATP-binding cassette (ABC) transporter subfamily D member 1 protein (ABCD1), which is referred to as the adrenoleukodystrophy protein (ALDP).
|
23437103 |
2013 |
|
Adrenoleukodystrophy
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
X-linked adrenoleukodystrophy (X-ALD) is a fatal neurodegenerative disease caused by mutations in the ABCD1 gene, encoding a member of the peroxisomal ABC transporter family.
|
24363066 |
2014 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cancer stem cell marker (CD44v6 and ABCG2) expression was detected by immunohistochemistry.
|
24504189 |
2014 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cancer stem cell marker (CD44v6 and ABCG2) expression was detected by immunohistochemistry.
|
24504189 |
2014 |
|
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lung cancer cell line NCI-H460 and its ABCG2-overexpressing NCI-H460/MX20, as well as the ABCG2-, ABCB1-, and ABCC10-overexpressing transfected cell lines were used for the reversal study.
|
24939447 |
2014 |
|
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lung cancer cell line NCI-H460 and its ABCG2-overexpressing NCI-H460/MX20, as well as the ABCG2-, ABCB1-, and ABCC10-overexpressing transfected cell lines were used for the reversal study.
|
24939447 |
2014 |
|
Primary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lung cancer cell line NCI-H460 and its ABCG2-overexpressing NCI-H460/MX20, as well as the ABCG2-, ABCB1-, and ABCC10-overexpressing transfected cell lines were used for the reversal study.
|
24939447 |
2014 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Breast cancer resistant protein (BCRP/ABCG2), a 72kDa plasma membrane transporter protein is a member of ABC transporter superfamily.
|
28916341 |
2017 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Breast cancer resistant protein (BCRP/ABCG2), a 72kDa plasma membrane transporter protein is a member of ABC transporter superfamily.
|
28916341 |
2017 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 involved in drug export.
|
29367724 |
2018 |